N200 and P300 component changes in Parkinson’s disease: a meta-analysis

Xu, Hui; Gu, Lihua; Zhang, Shiyao; Wu, Yi-Chun; Wei, Xuan; Wang, Caiyan; Xu, Yuhan; Guo, Yijing

doi:10.1007/s10072-022-06348-6

Cited by 10 publications

(7 citation statements)

References 64 publications

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“…This compelling finding led to the inference that as attention and working memory deteriorate in PD, the latency of P300 increases, potentially signifying an early dysfunction in the processing of cognitive information and attention. Another recent study revealed similar differences in P300 amplitude between PD patients with minimal cognitive impairment (MCI) and cognitive-normal (CN) PD patients, further supporting the notion that P300 amplitude may serve as a valuable marker for identifying early cognitive impairments related to attention and information processing in PD [21,22]. Similar differences were demonstrated in an additional study that specifically examined early-stage drug-naive (ESDN) PD patients.…”

Section: Introductionsupporting

confidence: 53%

“…P300 latency was prolonged in PD patients when compared to healthy controls [20]. In a recent comprehensive meta-analysis focusing on N200 and P300 components in PD patients, it was observed that the P300 effect was predominantly evident at the Fz site, with no significant variations detected at other electrode sites [21]. Intriguingly, the analysis also revealed that the P300 latency in PD patients diagnosed with dementia (PDD) was notably prolonged when compared to their non-dementia PD counterparts (PDND).…”

Section: Introductionmentioning

confidence: 95%

“…More generally, the N200 component has been described in tasks that reflect stimulus identification, attentional shifts, the inhibition of motor responses, overcoming stereotypical responses or conflict monitoring, the maintenance of context information, response selection timing, and the detection of novelty or mismatch [20,[24][25][26][27]. N200 amplitude had shown to be decreased in PD patients in comparison to healthy controls [21,[28][29][30]. These findings may suggest that in initial stages of stimulus processing, PD patients could be impaired in mismatch detection and the subsequent classification of a presented stimulus as standard, target, and distracter [29].…”

Section: Introductionmentioning

confidence: 99%

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Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation

Shkury,

Danziger-Schragenheim,

Katzir

et al. 2023

Sensors

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Background: The G2019S-LRRK2 gene mutation is a common cause of hereditary Parkinson’s disease (PD), associated with a higher frequency of the postural instability gait difficulty (PIGD) motor phenotype yet with preserved cognition. This study investigated neurophysiological changes during motor and cognitive tasks in PD patients with and without the G2019S-LRRK2 mutation. Methods: 33 iPD patients and 22 LRRK2-PD patients performed the visual Go/NoGo task (VGNG) during sitting (single-task) and walking (dual-task) while wearing a 64-channel EEG cap. Event-related potentials (ERP) from Fz and Pz, specifically N200 and P300, were extracted and analyzed to quantify brain activity patterns. Results: The LRRK2-PD group performed better in the VGNG than the iPD group (group*task; p = 0.05). During Go, the iPD group showed reduced N2 amplitude and prolonged N2 latency during walking, whereas the LRRK2-PD group showed only shorter latency (group*task p = 0.027). During NoGo, opposite patterns emerged; the iPD group showed reduced N2 and increased P3 amplitudes during walking while the LRRK2-PD group demonstrated increased N2 and reduced P3 (N2: group*task, p = 0.010, P3: group*task, p = 0.012). Conclusions: The LRRK2-PD group showed efficient early cognitive processes, reflected by N2, resulting in greater neural synchronization and prominent ERPs. These processes are possibly the underlying mechanisms for the observed better cognitive performance as compared to the iPD group. As such, future applications of intelligent medical sensing should be capable of capturing these electrophysiological patterns in order to enhance motor–cognitive functions.

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Section: Introductionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation

Shkury,

Danziger-Schragenheim,

Katzir

et al. 2023

Sensors

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“…Early PD patients with cognitive deficits exhibited significantly larger P300 and N200 components and smaller amplitude N200 components, indicating impaired neuronal processing [ 320 ]. A meta-analysis showed prolonged N200 and P300 latencies in PD non-demented (PD-ND) individuals, compared to HCs, and prolonged P300 latency at the Cz electrode site in PDD patients compared to PD-ND ones [ 321 ].…”

Section: Neurophysiological Studies In Pd-cimentioning

confidence: 99%

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

Jellinger

2023

IJMS

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Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD) that poses a severe burden on the patients and caregivers, yet relatively little is known about its pathobiology. Cognitive deficits are evident throughout the course of PD, with around 25% of subtle cognitive decline and mild CI (MCI) at the time of diagnosis and up to 83% of patients developing dementia after 20 years. The heterogeneity of cognitive phenotypes suggests that a common neuropathological process, characterized by progressive degeneration of the dopaminergic striatonigral system and of many other neuronal systems, results not only in structural deficits but also extensive changes of functional neuronal network activities and neurotransmitter dysfunctions. Modern neuroimaging studies revealed multilocular cortical and subcortical atrophies and alterations in intrinsic neuronal connectivities. The decreased functional connectivity (FC) of the default mode network (DMN) in the bilateral prefrontal cortex is affected already before the development of clinical CI and in the absence of structural changes. Longitudinal cognitive decline is associated with frontostriatal and limbic affections, white matter microlesions and changes between multiple functional neuronal networks, including thalamo-insular, frontoparietal and attention networks, the cholinergic forebrain and the noradrenergic system. Superimposed Alzheimer-related (and other concomitant) pathologies due to interactions between α-synuclein, tau-protein and β-amyloid contribute to dementia pathogenesis in both PD and dementia with Lewy bodies (DLB). To further elucidate the interaction of the pathomechanisms responsible for CI in PD, well-designed longitudinal clinico-pathological studies are warranted that are supported by fluid and sophisticated imaging biomarkers as a basis for better early diagnosis and future disease-modifying therapies.

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“…The most frequently assessed ERP component, P300 potential, reflects conscious information processing and decision making [ 20 , 21 ]. ERPs have been widely used in the evaluation of cognitive impairment in the course of various CNS disorders [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Event-Related Potentials in Assessing Cognitive Functions of Adult Patients with Epilepsy of Unknown Etiology

Jeżowska-Jurczyk

Jurczyk

Budrewićz

et al. 2023

JCM

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Background: Cognitive impairment (CI) is an important consequence of epilepsy. The aim of the study was to assess cognitive performance in patients with epilepsy, using neuropsychological tests (NT) and event-related potentials (ERPs), with regard to demographic and clinical data. Methods: The study comprised 50 patients with epilepsy of unknown etiology and 46 healthy controls. Based on the NT results, the patients were divided into subgroups with/without CI. Parameters of P300 potential were compared between the patients and controls. P300 parameters and NT results were referred to demographics and clinical characteristics of epilepsy. Results: Based on the NT, 66% of patients were assigned as cognitively impaired. Median P300 latency was significantly (p < 0.0002) prolonged in the study group. Subgroups of patients with and without CI significantly (p < 0.034) differed in education level and vocational activity, duration of epilepsy, age at its onset and frequency of polytherapy. P300 parameters showed significant (p < 0.03) relationships with duration of epilepsy, type and frequency of seizures and polytherapy. Conclusions: Cognitive impairment and ERPs abnormalities occur in a majority of patients with epilepsy of unknown etiology. Characteristics of epilepsy and socioeconomic status are related to cognitive performance. ERPs may complement neuropsychological methods in the assessment of cognition in patients with epilepsy.

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N200 and P300 component changes in Parkinson’s disease: a meta-analysis

Cited by 10 publications

References 64 publications

Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation

Differences in EEG Event-Related Potentials during Dual Task in Parkinson’s Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

Evaluation of Event-Related Potentials in Assessing Cognitive Functions of Adult Patients with Epilepsy of Unknown Etiology

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