N′-(α-Aminoacyl)- and N′-α-(Nα-Alkylamino)acyl Derivatives of Vancomycin and Eremomycin

Preobrazhenskaya, M. N.; Olsufyeva, Eugenia N.; Miroshnikova, Olga V; Plattner, J. J.; Chu, Daniel T. W.; Printsevskaya, Svetlana S.

doi:10.1038/ja.2007.28

Cited by 6 publications

(2 citation statements)

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“…4), an ATa rst isolated in 1994 from Trichoderma Fig. 4 Structure of putative ATa siderophores, C 12 -TA (5) and harzianic acid (14), and of the structurally related reutericyclin (38).…”

Section: -Acyltetramic Acids As Siderophoresmentioning

confidence: 99%

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

Zaghouani

Nay

2016

Nat. Prod. Rep.

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Covering: up to 20153-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

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Section: -Acyltetramic Acids As Siderophoresmentioning

confidence: 99%

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

Zaghouani

Nay

2016

Nat. Prod. Rep.

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“…An enormous collection of derivatives of glycopeptide antibiotics has been synthesized by numerous research groups throughout the years [5][6][7][8][9][10][11][12] to yield compounds that are active against resistant Gram-positive bacteria, unlike the original molecules. In several cases, the chemical modifications did not only improve the antibacterial spectrum or activity but also many of them came out to be superior to the parent compounds.…”

Section: Introductionmentioning

confidence: 99%

Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci

et al. 2017

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A selection of nine derivatives of teicoplanin pseudoaglycon were tested in vitro against clinical vancomycin-resistant Enterococcus strains possessing vanA, vanB or both genes. The bacteria were characterized by PCR for the identification of their resistance genes. The tested compounds contain lipoic acid, different carbohydrates and aryl groups as lipophilic moieties. About one-third of the teicoplanin-resistant strains were shown to be susceptible to one or more of the glycopeptide derivatives.

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Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis

Tanaka¹,

Dietrich²,

Ciblat³

et al. 2010

Bioorganic & Medicinal Chemistry Letters

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N′-(α-Aminoacyl)- and N′-α-(Nα-Alkylamino)acyl Derivatives of Vancomycin and Eremomycin

Cited by 6 publications

References 0 publications

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?

Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci

Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis

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