N<sub>2</sub>S<sub>2</sub>-Donor Macrocycles with Some Transition Metal Ions: Synthesis and Characterization

Nasman, Omar S.M.

doi:10.1080/10426500701690939

Cited by 12 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed magnetic moment for the Mn(II) complex 5.1 B.M is typical for tetrahedral geometry [19]. The electronic spectrum of the Co(II) complex is consistent with tetrahedral assignment [26, 28]. The spectrum of the Co(II) complex exhibited band characteristic of tetrahedral Co(II) complexes [26–29].…”

Section: Resultsmentioning

confidence: 81%

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Ahmed

Yousif

Hasan

et al. 2013

The Scientific World Journal

View full text Add to dashboard Cite

A new macrocyclic multidentate Schiff-base ligand Na4L consisting of two submacrocyclic units (10,21-bis-iminomethyl-3,6,14,17-tricyclo[17.3.1.18,12]tetracosa-1(23),2,6,8,10,12(24),13,17,19,21,-decaene-23,24-disodium) and its tetranuclear metal complexes with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) are reported. Na4L was prepared via a template approach, which is based on the condensation reaction of sodium 2,4,6-triformyl phenolate with ethylenediamine in mole ratios of 2 : 3. The tetranuclear macrocyclic-based complexes were prepared from the reaction of the corresponding metal chloride with the ligand. The mode of bonding and overall geometry of the compounds were determined through physicochemical and spectroscopic methods. These studies revealed tetrahedral geometries about Mn, Co, and Zn atoms. However, square planar geometries have been suggested for NiII and CuII complexes. Biological activity of the ligand and its metal complexes against Gram positive bacterial strain Staphylococcus aureus and Gram negative bacteria Escherichia coli revealed that the metal complexes become more potentially resistive to the microbial activities as compared to the free ligand. However, these metal complexes do not exhibit any effects on the activity of Pseudomonas aeruginosa bacteria. There is therefore no inhibition zone.

show abstract

Section: Resultsmentioning

confidence: 81%

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Ahmed

Yousif

Hasan

et al. 2013

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…The spectra of the complexes show intense broad band at 360 ± 10 nm due to metal to ligand charge transfer transitions (Iskander, El‐Sayed, Salem, Werner, & Haase, ; Sorrell, O'Connor, Anderson, & Reibenspies, ). The π → π* transition due to the aromatic ring (Bosnich, ; Nasman, ) appears at higher energy and exhibits an intense broad band in the region of 260 ± 5 nm.…”

Section: Resultsmentioning

confidence: 99%

“…The π ! π* transition due to the aromatic ring (Bosnich, 1968;Nasman, 2008) appears at higher energy and exhibits an intense broad band in the region of 260 ± 5 nm.…”

Section: Uv-vis Spectramentioning

confidence: 99%

Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

Arafath

Al‐Suede

Adam

et al. 2019

Drug Development Research

View full text Add to dashboard Cite

The bidentate N‐cyclohexyl‐2‐(3‐hydroxy‐4‐methoxybenzylidene)hydrazine‐1‐carbothioamide Schiff base ligand (HL) was coordinated to divalent nickel, palladium and platinum ions to form square planar complexes. The nickel and palladium complexes, [NiL2], [PdL2] form square planar complexes with 2:1 ligand to metal ratio. The platinum complex, [PtL(dmso)Cl] formed a square planar complex with 1:1 ligand to metal ratio. Platinum undergoes in situ reaction with DMSO before complexing with the ligand in solution. The cytotoxicity of HL, [NiL2], [PdL2], and [PtL(dmso)Cl] were evaluated against human colon cancer cell line (HCT‐116), human cervical cancer (Hela) cell line, melanoma (B16F10) cells, and human normal endothelial cell lines (Eahy926) by MTT assay. The [NiL2] complex displayed selective cytotoxic effect against the HCT 116 cancer cell line with IC50 of 7.9 ± 0.2 μM. However, HL, [PdL2], and [PtL(dmso)Cl] only exhibited moderate cytotoxic activity with IC50 = 75.9 ± 2.4, 100.0 ± 1.8, and 101.0 ± 3.6 μM, respectively. The potent cytotoxicity of [NiL2] was characterized using Hoechst and Rhodamine assays. The nickel complex, [NiL2], caused remarkable nuclear condensation and reduction in mitochondrial membrane potential. In addition, molecular docking studies confirms that [NiL2] possesses significant binding efficiency with Tyrosine kinase. Altogether, the results revealed that [NiL2] exhibits cytotoxicity against the cancer cells via Tyrosine kinase‐induced proapoptosis pathway. This study demonstrates that the [NiL2] complex could be a promising therapeutic agent against colorectal carcinoma.

show abstract

“…Presence of the new weak intensity absorption bands near 427-418 cm -1 corresponding to Te-N vibration also supports the formation of tellurium containing macrocyclic ring 30 . Further medium to weak intensity bands in the far infrared region, 308-318 cm -1 may reasonably be assigned to ν(Ni-Cl) vibration [42][43][44] .…”

Section: Infrared Spectramentioning

confidence: 94%

Investigations on Some Biologically Active Divalent Transition Metal Complexes with Ditellurium Tetraazamacrocycles

2018

Chem Sci Trans

View full text Add to dashboard Cite

Some 10-membered ditellurium tetraazamacrocyclic complexes of Ni(II), Pd(II) and Pt(II) were synthesized by template condensation of diaryltellurium(IV) dichlorides, (aryl = pmethoxyphenyl, 3-methyl-4-hydroxyphenyl and p-hydroxyphenyl) with 1,2-diaminopropane and divalent metal chlorides in dry methanol. Characterization of these newly synthesized complexes was carried out by elemental analyses, magnetic susceptibility measurement and Infrared, proton nuclear magnetic resonance and electronic absorption spectroscopy. On the basis of these studies, a square planar geometry has been assigned for Pd(II) and Pt(II) complexes and a distorted octahedral geometry for the Ni(II) complexes. The antibacterial and antifungal activities of these complexes, have also been screened in vitro against some pathogenic fungal and bacterial strains to assess their growth inhibiting potential. The MIC shown by these complexes were compared with the MIC shown by standard antifungal (fluconazole) and antibacterial (cefadroxil) drugs.

show abstract

N₂S₂-Donor Macrocycles with Some Transition Metal Ions: Synthesis and Characterization

Cited by 12 publications

References 22 publications

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

Investigations on Some Biologically Active Divalent Transition Metal Complexes with Ditellurium Tetraazamacrocycles

Contact Info

Product

Resources

About

N2S2-Donor Macrocycles with Some Transition Metal Ions: Synthesis and Characterization

Cited by 12 publications

References 22 publications

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Metal Complexes of Macrocyclic Schiff‐Base Ligand: Preparation, Characterisation, and Biological Activity

Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

Investigations on Some Biologically Active Divalent Transition Metal Complexes with Ditellurium Tetraazamacrocycles

Contact Info

Product

Resources

About

N₂S₂-Donor Macrocycles with Some Transition Metal Ions: Synthesis and Characterization