Investigations on Some Biologically Active Divalent Transition Metal Complexes with Ditellurium Tetraazamacrocycles

Abstract

Some 10-membered ditellurium tetraazamacrocyclic complexes of Ni(II), Pd(II) and Pt(II) were synthesized by template condensation of diaryltellurium(IV) dichlorides, (aryl = pmethoxyphenyl, 3-methyl-4-hydroxyphenyl and p-hydroxyphenyl) with 1,2-diaminopropane and divalent metal chlorides in dry methanol. Characterization of these newly synthesized complexes was carried out by elemental analyses, magnetic susceptibility measurement and Infrared, proton nuclear magnetic resonance and electronic absorption spectroscopy. On the basis of these studies, a square planar geometry has been assigned for Pd(II) and Pt(II) complexes and a distorted octahedral geometry for the Ni(II) complexes. The antibacterial and antifungal activities of these complexes, have also been screened in vitro against some pathogenic fungal and bacterial strains to assess their growth inhibiting potential. The MIC shown by these complexes were compared with the MIC shown by standard antifungal (fluconazole) and antibacterial (cefadroxil) drugs.