N-nitrosodimethylamine in air

Fine, David H.; Rounbehler, David P.; Pellizzari, Edo D.; Bunch, John E.; Berkley, Richard W.; McCrae, John P.; Bursey, Joan T.; Sawîckî, Eugene; Krost, Ken; DeMarrais, Gerard A.

doi:10.1007/bf01685626

Cited by 39 publications

(13 citation statements)

References 4 publications

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“…The use of permeation devices to generate calibration gas mixtures is a fairly widely used technique (1)(2)(3)(4)(5)(6)(7). Permeation, or effusion, of a compound through a membrane will occur at a constant rate if the ratio of the concentration of the compound on either side of the membrane is constant.…”

Section: Literature Cited Environmental Protection Agency Research Tr...mentioning

confidence: 99%

“…surement at the sub-microgram level in air, water, food, and other materials has been proposed (3)(4)(5). Since DMN can form from dimethylamine (DMA) and oxides of nitrogen (NO,), the apparent need to determine DMN in air near areas handling DMA has arisen.…”

mentioning

confidence: 99%

“…Since DMN can form from dimethylamine (DMA) and oxides of nitrogen (NO,), the apparent need to determine DMN in air near areas handling DMA has arisen. One published method (3) based upon cryogenic trapping of DMN followed by extraction, concentration, and measurement by combination gas chromatography / Thermal Energy Analyzer (GC/TEA) has been reported to be capable of this analysis. Other publications (2,6) have described the measurement of DMN in air through the use of a porous polymer trapping system followed by thermal desorption, separation by GC, and measurement by mass spectrometry.…”

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confidence: 99%

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Determination of sub-microgram per cubic meter levels of N-nitrosodimethylamine in air

Rl¹,

Rw²,

Ba³

1977

Anal. Chem.

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Ambient-temperature caustic impinger traps were used in parallel sampling with cryogenic caustic traps to study the degree of conversion of dimethylamine (DMA) to A/-nitrosodimethylamine (DMN) when DMA and NO" were brought together by trapping. Under simulated use conditions where DMA at sub-ppm (0.05) and NO, (0.2 ppm) from light traffic were brought together by trapping, the cryogenic traps produced from one to two orders of magnitude more DMN than the ambient traps. For routinely measuring DMN in air, ambient trapping in caustic followed by combination gas chromatography-mass spectrometry readout has been shown to produce artifact-free results.Recent literature reports have expressed concern that N-nitrosodimethylamine (DMN) may be a widespread environmental contaminant which may have implications as a human carcinogen (1, 2). The necessity for DMN mea-

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Section: Literature Cited Environmental Protection Agency Research Tr...mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Determination of sub-microgram per cubic meter levels of N-nitrosodimethylamine in air

Rl¹,

Rw²,

Ba³

1977

Anal. Chem.

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“…Under the effect of NO 2 , oxygen, sunlight, elevated temperatures, biota, soil, and water constituents [7–9], UDMH transforms into a number of potentially dangerous substances – amines, nitrosoamines, triazoles, pyrazoles, and amides [10,11]. Among all known UDMH transformation products (TPs), the most studied are amines, nitrosoamines, and formamides [12–15]. Main UDMH TPs such as N ‐nitrosodimethylamine (NDMA), N,N ‐dimethylformamide (DMF) are known carcinogens, mutagens, and/or teratogens [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…In Kazakhstan, only NDMA is regulated by hygienical standards – 0.1 μg/m 3 in ambient air of populated areas and 10 μg/m 3 in occupational air [19]. Despite the importance of monitoring UDMH TPs in air, methods of analysis and data on concentrations of UDMH TPs in air are very scarce [15,20], particularly compared to soil [2,4,21,22]. This is caused by the lack of analytical methods, which are not available for most UDMH TPs.…”

Section: Introductionmentioning

confidence: 99%

Quantification of transformation products of rocket fuel unsymmetrical dimethylhydrazine in air using solid‐phase microextraction

Bukenov

Baimatova

Kenessov

2021

J of Separation Science

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Quantification of unsymmetrical dimethylhydrazine transformation products in ambient air is important for assessing the environmental impact of heavy rocket launches. There are very little data of such analyses, which is mainly caused by the low number of analytes covered by the available analytical methods and their complexity. A simple and cost‐efficient method for accurate simultaneous determination of seven unsymmetrical dimethylhydrazine transformation products in air using solid‐phase microextraction followed by gas chromatography‐mass spectrometry was developed. The method was optimized for air sampling and solid‐phase microextraction from 20‐mL vials, which allows full automation of analysis. The extraction for 5 min by Carboxen/polydimethylsiloxane fiber from amber vials and desorption for 3 min provided the greatest analytes' responses, lowest relative standard deviations, linear calibration (R2 ≥ 0.99), and limits of detection from 0.12 to 0.5 μg/m3. Samples with concentrations 500 μg/m3 can be stored at 21 ± 1°C without substantial losses (1–11%) for up to 24 h, while air samples with concentrations 10 and 50 μg/m3 stored for up to 24 h can be used for accurate quantification of only two and four out of seven analytes, respectively. The developed method was successfully tested for the analysis of air above real soil samples contaminated with unsymmetrical dimethylhydrazine rocket fuel.

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Die Nitrosierung flüchtiger Amine am Arbeitsplatz [MAK Value Documentation in German language, 1984]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 10. Lieferung, Ausgabe 1984 Der Artikel enthält folgende Kapitel: Einleitung Mechanismus der Nitrosierungsreaktion Nitrosierung in der Gasphase Nitrosaminbildung am Arbeitsplatz Nitrosaminbildung außerhalb des menschlichen Organismus in vivo‐Nitrosaminbildung Mutagenität durch Nitrosierungsreaktionen Zusammenfassung

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N-nitrosodimethylamine in air

Cited by 39 publications

References 4 publications

Determination of sub-microgram per cubic meter levels of N-nitrosodimethylamine in air

Determination of sub-microgram per cubic meter levels of N-nitrosodimethylamine in air

Quantification of transformation products of rocket fuel unsymmetrical dimethylhydrazine in air using solid‐phase microextraction

Die Nitrosierung flüchtiger Amine am Arbeitsplatz [MAK Value Documentation in German language, 1984]

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