N,N-disubstituted 2-aminothiazole-5-carboxylates: preparation and rotation of functional groups

Kaye, Perry T.; Meakins, G. D.; Smith, Anthony K.; Tirel, Malcolm D.

doi:10.1039/p19830001677

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Synthesis Of Thioureas and Thiazoles1

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1983

2015

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Cited by 11 publications

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“…2-Aminothiazole-5-carboxylates are readily prepared by the condensation of a thiourea with a 2-haloacetoacetate …”

Section: Synthesis Of Thioureas and Thiazolesmentioning

confidence: 99%

Trityl Isothiocyanate Support for Solid-Phase Synthesis

Pirrung

Pansare

2000

J. Comb. Chem.

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Trityl isothiocyanate resin [1], prepared from commercially available trityl chloride resin, is a useful precursor of the trityl thiosemicarbazide resin [2]. This resin can be employed in the solid-phase synthesis of a variety of supported isatin beta-thiosemicarbazones [4] and their Mannich derivatives [6]. A variety of thioureas [7] can be easily prepared by the reaction of [1] with amines. The supported thioureas are directly and efficiently converted to 2-aminothiazole-5-carboxylates [8] by reaction with methyl 2-chloroacetoacetate.

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“…2-Aminothiazole-5-carboxylates are readily prepared by the condensation of a thiourea with a 2-haloacetoacetate …”

Section: Synthesis Of Thioureas and Thiazolesmentioning

confidence: 99%