N,N′-Alkylene-bis(Acrylamides), N-(Acrylamidomethyl)-3-Halopropionamides and Related Compounds : a New Series of Anti-tumour Agents

Synthesis and characterization of a novel organic–inorganic hybrid salt and its application as a highly effectual Brønsted–Lewis acidic catalyst for the production of N,N′‐alkylidene bisamides

“…[11][12][13][14][15][16][17][18][19] Bisamide functional group can be found in the scaffold of a wide range of biologically, pharmaceutically, and industrially important compounds. [20][21][22][23][24][25][26][27][28][29][30][31] Bisamides have been used as ligands for the preparation of biologically active compounds in the Ullmann reaction [20] and as essential moieties to introduce gem-diaminoalkyl groups in retro-inverse pseudo-peptide materials. [21] These compounds have been utilized in the synthesis of peptidomimetic compounds.…”

“…[ 21 ] These compounds have been utilized in the synthesis of peptidomimetic compounds. [ 22 ] Bisamide‐containing compounds have been also applied as drug release, [ 23 ] antitumor, [ 24 ] anti‐inflammatory, [ 25 ] and antimicrobial [ 25 ] agents. Moreover, bisamides coordinated with metal ions have been utilized for bimodal (optical/magnetic resonance) imaging, [ 26 ] magnetic resonance imaging (MRI) blood‐pool contrasting, [ 27 ] and removal of organic dyes [ 28 ] and as inhibitor against α‐glucosidase [ 29 ] and reagents in organic synthesis.…”

N,N,N′,N′-Tetramethylethylene-diaminium-N,N′-disulfonic acid trifluoroacetate and pyridinium-N-sulfonic acid hydrogen sulfate as highly effective dual-functional catalysts for the preparation of N,N′-alkylidene bisamides

“…Additionally, these compounds are used in the synthesis of peptidomimetic materials [21,22], and as ligands in the Ullmann reaction leading to potentially pharmacologically active compounds [23]. Bisamides are also applied as antitumor [24] and insecticide [25] agents. Applications in polymerizations [26] and in the separation of xylene isomers [27] have also been reported.…”