N-methyl-d-aspartate triggers neonatal rat hypoglossal motoneurons in vitro to express rhythmic bursting with unusual Mg2+ sensitivity

Sharifullina, Elina; Ostroumov, Konstantin; Grandolfo, Micaela; Nistri, Andrea

doi:10.1016/j.neuroscience.2008.03.010

Cited by 13 publications

(17 citation statements)

References 81 publications

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“…Bursts are, therefore, the summated expression of synchronized depolarization and firing occurring in a group of motoneurons. This interpretation accords with the poor voltage sensitivity of bursts (Sharifullina et al 2005(Sharifullina et al , 2008 because their origin comes from functionally interconnected cells rather than from ligand and/or voltage-gated channels of single motoneurons.…”

Section: Factors Responsible For Motoneuron Burstingsupporting

confidence: 68%

“…Nevertheless, sustained NMDA-dependent bursting detected in the majority of motoneurons requires the drive by a few (electrically coupled) motoneurons that continuously burst (or fire) and, thus, provide strong excitation to the functionally coupled network of motoneurons. This notion is supported by the presence of hypoglossal nerve bursting even when concomitant recording from a single motoneuron shows burst fading (Sharifullina et al 2008).…”

Section: Factors Responsible For Motoneuron Burstingmentioning

confidence: 89%

“…or inhibitory synaptic transmission (Sharifullina et al 2008), and that is preserved despite fluctuations in extracellular Mg 2þ . Activation of NMDA receptors is not the only glutamatergic stimulus to induce bursting.…”

Section: Heterogeneity Of Motoneuron Rhythmic Bursting Evoked By Neurmentioning

confidence: 99%

“…Nevertheless, such motoneurons can produce persistent bursts (0.43 + 0.07 Hz) when excited by the glutamate agonist N-methyl-Daspartate (NMDA) (figure 1a). This activity is reversibly blocked by inorganic Ca 2þ channel blockers like Cd 2þ (Sharifullina et al 2008;figure 1a). Conversely, the Na þ channel blocker tetrodotoxin can suppress bursting in a few motoneurons only.…”

Section: Heterogeneity Of Motoneuron Rhythmic Bursting Evoked By Neurmentioning

confidence: 99%

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A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

Cifra

Nani

Sharifullina

et al. 2009

Phil. Trans. R. Soc. B

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The brainstem nucleus hypoglossus contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements, tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease often associated with a deficit in the transport system of the neurotransmitter glutamate.The present study shows how periodic electrical discharges of motoneurons are mainly produced by a neuronal network that drives them into bursting mode via glutamatergic excitatory synapses. Burst activity is, however, modulated by the intrinsic properties of motoneurons that collectively synchronize their discharges via gap junctions to create 'group bursters'. When glial uptake of glutamate is blocked, a distinct form of pathological bursting spontaneously emerges and leads to motoneuron death. Conversely, H 2 O 2 -induced oxidative stress strongly increases motoneuron excitability without eliciting bursting. Riluzole (the only drug currently licensed for the treatment of ALS) suppresses bursting of hypoglossal motoneurons caused by blockage of glutamate uptake and limits motoneuron death. These findings highlight how different patterns of electrical oscillations of brainstem motoneurons underpin not only certain physiological activities, but also motoneuron death induced by glutamate transporter impairment.

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Section: Factors Responsible For Motoneuron Burstingsupporting

confidence: 68%

Section: Factors Responsible For Motoneuron Burstingmentioning

confidence: 89%

Section: Heterogeneity Of Motoneuron Rhythmic Bursting Evoked By Neurmentioning

confidence: 99%

Section: Heterogeneity Of Motoneuron Rhythmic Bursting Evoked By Neurmentioning

confidence: 99%

See 2 more Smart Citations

A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

Cifra

Nani

Sharifullina

et al. 2009

Phil. Trans. R. Soc. B

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show abstract

“…This important role of NMDA receptors in development maybe related to permeability of this receptor to calcium, intracellular calcium has a role in neuronal development. An interesting effect of NMDA-receptor activation by exogenously applied NMDA onto neonatal rat HMs in vitro, was the finding in many but not all motoneurons that this resulted in bursting behavior (Sharifullina et al, 2008). The similarity of the observed NMDA-evoked bursting pattern to that previously recorded during suckling led to the suggestion that suckling during the postnatal period may involve NMDA-receptor activation on HMs.…”

Section: Glutamatergic Synaptic Transmissionmentioning

confidence: 99%

Development of synaptic transmission to respiratory motoneurons

Berger

2011

Respiratory Physiology & Neurobiology

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Respiratory motoneurons provide the exclusive drive to respiratory muscles and therefore are a key relay between brainstem neural circuits that generate respiratory rhythm and respiratory muscles that control moment of gases into and out of the airways and lungs. This review is focused on postnatal development of fast ionotropic synaptic transmission to respiratory motoneurons, with a focus on hypoglossal motoneurons (HMs). Glutamatergic synaptic transmission to HMs involves activation of both non-NMDA and NMDA receptors and during the postnatal period co-activation of these receptors located at the same synapse may occur. Further, the relative role of each receptor type in inspiratory-phase motoneuron depolarization is dependent on the type of preparation used (in vitro versus in vivo; neonatal versus adult). Respiratory motoneurons receive both glycinergic and GABAergic inhibitory synaptic inputs. During inspiration phrenic and HMs receive concurrent excitatory and inhibitory synaptic inputs. During postnatal development in HMs GABAergic and glycinergic synaptic inputs have slow kinetics and are depolarizing and with postnatal development they become faster and hyperpolarizing. Additionally shunting inhibition may play an important role in synaptic processing by respiratory motoneurons.

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Electrical Coupling in the Generation of Vertebrate Motor Rhythms

Rekling

2017

Network Functions and Plasticity

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N-methyl-d-aspartate triggers neonatal rat hypoglossal motoneurons in vitro to express rhythmic bursting with unusual Mg2+ sensitivity

Cited by 13 publications

References 81 publications

A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

Development of synaptic transmission to respiratory motoneurons

Electrical Coupling in the Generation of Vertebrate Motor Rhythms

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