N-isopropylacrylamide-based fine-dispersed thermosensitive ferrogels obtained via in-situ technique

Korotych, Olena; Samchenko, Yu. M.; Boldeskul, I. E.; Ulberg, Z. R.; Nm, Zholobak; Sukhodub, L. F.

doi:10.1016/j.msec.2012.11.017

Cited by 21 publications

(10 citation statements)

References 26 publications

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“…Consequently hybrid nanocomposites composed of metal [1][2][3], metal oxide [4][5][6] or non-metal [7][8][9][10] nanoparticles have been used for different applications. On-demand drug delivery is required when dosing and timing would produce an improved outcome of the pathology compared to conventional sustained or controlled delivery.…”

Section: Introductionmentioning

confidence: 99%

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Alejo

Andreu

Mendoza

et al. 2018

Journal of Colloid and Interface Science

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Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Alejo

Andreu

Mendoza

et al. 2018

Journal of Colloid and Interface Science

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“…It appeared that co-polymer hydrogels containing NIPA diphile chains are compatible with ethanol. Synthesis and properties of the above-mentioned hydrogel systems, as well as those of ferrogels based on them, are described in detail in [13], while the present work deals with the development of the techniques of optimizing provitamin D incorporation in the hydrogels .…”

Section: Resultsmentioning

confidence: 99%

Photoisomerization of Provitamin D in Hydrogel Matrix

Terenetskaya¹,

Samchenko²,

Orlova³

et al. 2013

Soft

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Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)-and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D 3 (7-dehydrocholesterol) and D 2 (ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active 'antirachitic' UV radiation.

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“…Via in-situ polymerization technique involving magnetite, NIPAAm and hydrophilic acrylamide crosslinked with N,N′-methylenebisacrylamide, Korotych et al developed hydrogel films sensitive to both physiological temperature and external magnetic field [15]. The synthesis of interpenetrating polymer networks by one-step polymerization of NIPAAm and calcium alginate has been reported by Petrusic et al [16].…”

Section: Introductionmentioning

confidence: 99%

Tunable thermo-responsive hydrogels: Synthesis, structural analysis and drug release studies

Cirillo

Spataro

Curcio

et al. 2015

Materials Science and Engineering: C

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N-isopropylacrylamide-based fine-dispersed thermosensitive ferrogels obtained via in-situ technique

Cited by 21 publications

References 26 publications

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Photoisomerization of Provitamin D in Hydrogel Matrix

Tunable thermo-responsive hydrogels: Synthesis, structural analysis and drug release studies

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