N-doped carbon dots derived from leaves with low toxicity via damaging cytomembrane for broad-spectrum antibacterial activity

Ma, Yurong; Zhang, Mengling; Wang, Huibo; Wang, Bo; Huang, Hui; Liu, Yang

doi:10.1016/j.mtcomm.2020.101222

Cited by 35 publications

(28 citation statements)

References 34 publications

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“…The deconvoluted high-resolution spectra of C1s ( Figure 3 b) presented three distinct peaks located at 284.9, 286.3, and 288.1 eV, corresponding to C–C, C–O/C–N, and C=O functional groups, respectively [ 42 , 43 , 44 ]. The two peaks at 400.1 and 402.3 eV in high-resolution spectra of N1s, which can be attributed to the presence of C–N and N-H groups, respectively [ 45 ]. In the O1s high-resolution spectra, two peaks at 531.2 and 532.5 eV are assigned to C=O (carbonyl) and C–O bonding [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

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Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

et al. 2021

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Carbon dots (CDs) were obtained from medicinal turmeric leaves (Curcuma longa) by a facile one-step hydrothermal method and evaluated for their bactericidal activities against two gram-negative; Escherichia coli, Klebsiella pneumoniae, and two gram-positive counterparts; Staphylococcus aureus, S. epidermidis. The CDs exhibited spherical shapes with a mean size of 2.6 nm. The fluorescence spectra of CDs revealed intense fluorescence at λex/em = 362/429 nm with a bright blue color in an aqueous solution. The CDs showed strong photostability under various environmental conditions (pH, salt, and UV-radiation). The complete bactericidal potency of CDs was 0.25 mg/mL for E.coli and S. aureus after 8 h of exposure, while for K. pneumoniae, and S. epidermidis, the CDs at 0.5 mg/mL good antibacterial effect within 8 h and complete eradication after 24 h of exposure is observed. The release of reactive oxygen species played a crucial role in the death of the bacterial cell. The present study provides a strategy for the preparation of CDs from a medicinal plant and their potential antibacterial activities against four common contagious pathogens.

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Section: Resultsmentioning

confidence: 99%

“…tributed to the presence of C-N and N-H groups, respectively [45]. In th high-resolution spectra, two peaks at 531.2 and 532.5 eV are assigned to C=O (car and C-O bonding [46].…”

Section: Ftir and Xpsmentioning

confidence: 99%

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

et al. 2021

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“…The outer surface of bacteria is attached to CDs leading to indirect proliferating inhibition [153][154][155]. These results prove the natural sources are essential for the synthesis of CDs [79]. As mentioned above, the tunability of raw material and diameters primarily affect the antibacterial efficiency and selectivity of the resultant CDs.…”

Section: Antibacterial Activitymentioning

confidence: 78%

“…Figure10. Graphs of E. coli and S. aureus incubated with varying concentrations of OCDs, TCDs, and MCDs for 24 h; alive ratio of E. coli and S. aureus calculated using UV-Vis spectroscopy methods, adapted with permission from[79], Elsevier, 2020.…”

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confidence: 99%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

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“…Nitrogen (as well as different heteroatoms such as P, O, and S) has also been incorporated during the CD synthesis using a mixture of different starting materials [ 61 ]. For example, the addition of polyamines [ 16 , 62 ], amino acids [ 63 , 64 , 65 , 66 , 67 ], or biomass such as plant leaves and fungi [ 68 , 69 , 70 , 71 , 72 , 73 , 74 ], food [ 75 , 76 , 77 , 78 , 79 ], and industrial [ 80 ] and waste derivatives [ 81 , 82 ], among others, have been used for the preparation of doped CDs. In this context, two independent comparative studies from the Kang [ 83 ] and Bandosz [ 84 ] research groups highlighted that N- or S-doped CDs exhibit very different antibacterial properties.…”

Section: Cds As Bacteria Targeting and Antibacterial Agentsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.

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N-doped carbon dots derived from leaves with low toxicity via damaging cytomembrane for broad-spectrum antibacterial activity

Cited by 35 publications

References 34 publications

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Carbon Dots as an Emergent Class of Antimicrobial Agents

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