Carbon Dots as an Emergent Class of Antimicrobial Agents

Ghirardello, Mattia; Ramos‐Soriano, Javier; Galan, M. Carmen

doi:10.3390/nano11081877

Cited by 85 publications

(62 citation statements)

References 151 publications

(183 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CDs are internalized into bacteria. The outer surface of bacteria is attached to CDs leading to indirect proliferating inhibition [153][154][155]. These results prove the natural sources are essential for the synthesis of CDs [79].…”

Section: Antibacterial Activitymentioning

confidence: 75%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

View full text Add to dashboard Cite

This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

show abstract

Section: Antibacterial Activitymentioning

confidence: 75%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Carbon dots (CDs) are a new type of nanomaterial that have attracted considerable attention because of their unique properties, including optical properties, good water solubility, low toxicity, biocompatibility, and cell permeability [170] . As a result of their exceptional chemical and photoelectric properties, CDs are great candidates for antibacterial theranostic applications [171] . Recently, Li et al [172] .…”

Section: Wound Biofilm Therapymentioning

confidence: 99%

Advances in the Sensing and Treatment of Wound Biofilms

et al. 2022

View full text Add to dashboard Cite

Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor‐based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point‐of‐care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound‐induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.

show abstract

“…8–11 Carbon dots have been widely applied in the detection of food contamination compounds, such as metal ions/anions, additives, pesticides, and veterinary drugs, as well as for microbial inhibition as antibacterial agents. 12–14 Kung et al synthesized negative-charged carbon dots from urea and citric acid with microwave method, and found good antimicrobial activity against multidrug-resistant bacteria with a minimum inhibitory concentration (MIC) of 0.63 mg mL −1 . 15 Ye et al prepared p -phenylenediamine carbon dots functionalized with –NH 3 + groups via one-step hydrothermal reaction, which showed strong bactericidal ability against Staphylococcus aureus and Escherichia coli.…”

Section: Introductionmentioning

confidence: 99%