N/C-4 substituted azetidin-2-ones: Synthesis and preliminary evaluation as new class of antimicrobial agents

Synthesis and antimicrobial activity of 5-chloroindoline-2,3-dione derivatives

“…Moreover, due to their b-lactamase inhibitory action, 2-azetidinone-based heterocycles represent an attractive target of contemporary organic synthesis. A large numbers of 2-azetidinones (Arnould et al, 1992;Halve et al, 2007;Keri et al, 2009) were reported to possess antibacterial and antifungal activity. The 4-thiazoldinone nucleus has drawn many attentions due to its various activities like antimicrobial (Vicini et al, 2008), anti-HIV (Chen et al, 2009;Rao et al, 2004;Rawal et al, 2005) anticancer (Abdel-Aziz et al, 2010;Lv et al, 2010) and antihypertensive (Bhandari et al, 2009).…”

Synthesis and Biological Activity of a Series of Novel N‐Substituted β‐Lactams Derived from Natural Gallic Acid

“…1) all contain the azetidine-2-one heterocycle, which is the core structural feature in a number of broad spectrum b-lactams derivatives. 7,8 Nowadays, with the development of resistance of bacteria towards the b-lactam antibiotics, the constant need for novel drugs displaying broader biological activity to combat the microorganisms that have built up a resistance against the most traditional drugs. 9,10 So the extensive interest of chemists into b-lactams have been maintained for decades.…”

4-phenyldiazenyl 2-(phenylimino methyl) phenols; synthesis and in-vitro biological evaluation as potential antibacterial agents

“…Many attempts have been made to synthesize, characterize and to study structure-activity relationship (SAR) of schiff bases [34][35][36][37]. In view of conclusions drawn from our previous work [38][39][40][41][42] and looking to the antimicrobial efficacy of ZSO 2 NH 2 , ZSO 2 NHC (NH) NH 2 , ZCl and ZOCH 3 moieties attached to aryl ring it seems logical and attractive to combine all these moieties together in a parent molecule. This study was aimed at exploring the potential antibacterial activity resulting from the combination of pharmacophores in one structure.…”