N-butyl cyanoacrylate- and alpha-cyanoacrylate induced hepatotoxicity and venous sclerosis in a rabbit model

Shehab, Amal A.; Elbatea, Hasan ElSayed; El-Din, Ibrahim S. Shehab; Elfert, Asem

doi:10.1016/j.ajg.2016.01.001

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Other scholars found that glue can cause neuronal necrosis, nerve fiber rupture and demyelination, and lead to T lymphocytes, mast cells and macrophages infiltration. It suggests that the application of medical glue to nervous tissue or other sensitive tissues must be carefully selected [17, 18]. In our early study, most patients did not have adverse reactions although medical glue was not completely removed from deep orbital lesions.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

Lin

Zhu

2018

BMC Ophthalmol

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BackgroundOrbital vascular malformation often encircles normal tissue with ill-defined borders. It is easy to bleed during resection operation, making surgical treatment difficult and lesions hard to be removed completely. In this study we aimed to summarize the treatment outcomes by embolizing orbital vascular malformation with intraoperative intracavitary injection of medical glue .MethodsA retrospective observational and cross-sectional case series study enrolled 31 patients (male = 9, female = 22) with orbital vascular malformations, who were treated from March 2008 to September 2017 at our institution. The clinical features, operation records, pathological reports and follow-up data were analyzed.ResultsThe location of vascular malformations involved intraorbital (14 cases), superficial area of eyelid and/or face (7 cases), both intraorbital and superficial area (10 cases). Imaging examination showed a solitary mass with regular shape in 8 cases and a space occupying lesion with irregular shape and ill-defined margins in 23 cases. There were 9 cases had optic nerve involved. Surgical debulkling were performed via skin incision on the mass surface (5 cases), lateral orbitotomy (2 cases), and anterior orbitotomy (24 cases). During the operation, lesions were partly exposed and injected with medical glue. The amount of injected glue was 0.25 ml to 2.5 ml in divided doses. The lesions and remnant glue were removed after the glue had turned hard. The whole procedure caused less bleeding and was easier performing than usual. Topical skin aseptic inflammation took place on the same side of the superficial eyelid lesions in 3 cases. One patient suffered from sudden central retinal artery embolism on the third day post operation. With timely rescue and appropriate procedure, visual acuity recovered to 20/32. There were no recurrences in 29 cases.ConclusionsEmbolization of orbital vascular malformation with medical glue intraoperatively made it easy to control hemorrhage. Surgeons should be careful with glue application methods in order to avoid complications.

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Section: Discussionmentioning

confidence: 99%

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

Lin

Zhu

2018

BMC Ophthalmol

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“…THLE-3 cell line used in this study is a kind of hepatic epithelial cells. It is known that toxic chemicals could enter the hepatic sinusoids when they are distributed in the liver with the blood in the body, and the toxic chemicals could progressively damage the sinusoidal epithelial cell wall (Shehab et al, 2016). Thus, the THLE-3 cell line was used in this in vitro study to investigate the hepatotoxicity of the two toxic chemicals.…”

Section: Discussionmentioning

confidence: 99%

Individual and combined hepatocytotoxicity of DDT and cadmium in vitro

Sun

Cao

et al. 2021

Toxicol Ind Health

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The organochlorine insecticide dichlorodiphenyltrichloroethane (DDT) and heavy metal cadmium (Cd) are widespread environmental pollutants. They are persistent in the environment and can accumulate in organisms. Although the individual toxicity of DDT and Cd has been well documented, their combined toxicity is still not clear. Since liver is their common target, in this study, the individual and combined toxicity of DDT and Cd in human liver carcinoma HepG2 and human normal liver THLE-3 cell lines were investigated. The results showed that DDT and Cd inhibited the viability of HepG2 and THLE-3 cells dose-dependently and altered lysosomal morphology and function. Intracellular reactive oxygen species and lipid peroxidation levels were induced by DDT and Cd treatment. The combined cytotoxicity of DDT and Cd was greater than their individual cytotoxicity, and the interaction between Cd and DDT was additive on the inhibition of cell viability and lysosomal function of HepG2 cells. The interaction was antagonistic on the inhibition of cell viability of THLE-3 cells. These results may facilitate the evaluation of the cumulative risk of pesticides and heavy metal residues in the environment.

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N-butyl cyanoacrylate- and alpha-cyanoacrylate induced hepatotoxicity and venous sclerosis in a rabbit model

Cited by 2 publications

References 8 publications

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

Individual and combined hepatocytotoxicity of DDT and cadmium in vitro

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