N-Alkenylimidazole Metal Complex Derivatives as Effective Agents for the Hypoxic Conditions

Шахмарданова, С А; Galenko-Yaroshevsky, P. A.

doi:10.18413/2500-235x-2017-3-1-49-72

Cited by 2 publications

(2 citation statements)

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“…This is due to several reasons: low awareness of dentists about this pathology, the lack of a clear algorithm for the management of such patients, and often insufficient effectiveness of the pharmacological agents for etiotropic and pathogenetic therapy. In addition, the lack of a fundamental basis in the morphological studies and objective data on the processes occurring in these tissues limits the ability of practicing dentists to effectively influence the lesions in the EPTC and effectively prevent the development of EPL (Morozov and Iordanishvili 2019; Moiseev et al 2021;Çirakoğlu and Karayürek 2021;Saroch 2021).…”

Section: Discussionmentioning

confidence: 99%

The effect of zinc complex of N-isopropenylimidazole on the morphological characteristics of gum tissues in experimental endodontic-periodontal lesions in rats

Galenko-Yaroshevsky,

Slavinskiy,

Todorov

et al. 2023

RRP

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Introduction: Combined inflammatory and destructive processes affecting the dental pulp and tissues of the periodontal complex are among the most problem diseases of the dental system. Current therapy with use of available pharmacological agents does not always allow achieving the expected positive result. In addition, often the lack of information about morphological processes in the tissues of the dental system, in particular the gums, with endodontic-periodontal lesion (EPL) limits the ability of dentists to carry out targeted pharmacotherapy with both traditional and, in particular, new medications. The aim of the study was to evaluate the morphological characteristics of gum tissues in a therapeutic context of N-isopropenylimidazole zinc complex derivative in experimental endodontic-periodontal lesion in rats. Materials and Methods: A simulation of EPL in rats was performed in two ways: simultaneous induction of acute periodontitis and parodontitis by pulp extraction and natural infection of the pulp cavity, as well as by ligation of the necks of lower incisors. The research protocols included 5 groups of animals: 1st – intact group (control-1); 2nd – animals with simulated EPL (control-2); 3rd – animals with simulated EPL and treated with Metrogyl Denta® gel (M-D); 4th – animals with simulated EPL and treated with N–isopropenylimidazole zinc complex derivative gel under the laboratory code Pilim-1; and 5th – animals with simulated EPL and treated with the combination of M-D + Pilim-1. The gum of the lower incisors was taken for morphological studies. Slides were stained with hematoxylin and eosin. Computer morphometry was performed using the ImageJ software. Results and Discussion: The substances M-D, Pilim-1 and, especially, the combination of M-D+Pilim-1 (against the background of chlorhexidine bigluconate used as oral rinse) for 14 days in rats with simulated EPL cause a significant improvement of the morphological structure of the gum with minimal residual dystrophy and sclerosis. The combination M-D + Pilim-1 led to a 1.3-time increase in epithelial thickness, and a 1.5-time decrease in acanthosis depth in comparison with M-D, while the number of capillaries and their diameter had no significant differences. Compared with Pilim-1, the epithelial thickness increased 1.5 times, and the acanthosis depth and the number of capillaries decreased 1.6 and 1.4 times, respectively, whereas the diameter of the capillaries did not change significantly. The pronounced protective effect of the combination M-D + Pilim-1 on the morphological structure of the gingival mucosa of rats with simulated EPL may be associated with antimicrobial, anti-inflammatory, regenerating, angioprotective and antioxidant properties of both M-D and Pilim-1 separately, and, possibly to a greater extent, of the combination M-D + Pilim-1. Conclusion: The substances M-D, Pilim-1 and, especially, the combination M-D + Pilim-1 (against the background of chlorhexidine bigluconate used as oral rinse) for 14 days in rats with simulated EPL have a protective effect on the epithelial structure and the connective tissue of the proper mucous plate, manifested in active normalization of pathological changes and significant restoration of their organotypic structure.

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Section: Discussionmentioning

confidence: 99%

The effect of zinc complex of N-isopropenylimidazole on the morphological characteristics of gum tissues in experimental endodontic-periodontal lesions in rats

Galenko-Yaroshevsky,

Slavinskiy,

Todorov

et al. 2023

RRP

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“…Interestingly, animal models of hypoxia showed a protective effect of Acyzol (at 38−176% compared to animals of the control groups). Briefly, Acyzol was administered in a wide dose range (10–150 mg/kg) in mice under various acute hypoxic conditions including hypobaric hypoxia (AHBH), hypoxia with hypercapnia (AHwHc), and hemic hypoxia (AHeH) (see Table 1) [98,99].…”

Section: Acyzol In the Treatment And Prevention Of Zdcmentioning

confidence: 99%

Application of Acyzol in the Context of Zinc Deficiency and Perspectives

Aliev

Chubarev

et al. 2019

IJMS

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Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad’s disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.

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N-Alkenylimidazole Metal Complex Derivatives as Effective Agents for the Hypoxic Conditions

Cited by 2 publications

References 0 publications

The effect of zinc complex of N-isopropenylimidazole on the morphological characteristics of gum tissues in experimental endodontic-periodontal lesions in rats

The effect of zinc complex of N-isopropenylimidazole on the morphological characteristics of gum tissues in experimental endodontic-periodontal lesions in rats

Application of Acyzol in the Context of Zinc Deficiency and Perspectives

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