Application of Acyzol in the Context of Zinc Deficiency and Perspectives

Abstract

Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad’s disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.

Potential health benefits of zinc supplementation for the management of COVID‐19 pandemic

“…Also, inadequacy of zinc in diets has been associated with attenuated activity of the osteoblast, and reduced synthesis of collagen and proteoglycans in the presence of reduced phosphatase activity (Tapiero & Tew, 2003). In addition to inadequate dietary zinc intake, deficiency of zinc may result from impaired absorption or resorption or increased excretion of zinc, and several pathologic statuses including chronic diarrhea, extensive burns, or traumatic and surgical wounds (Aliev et al., 2019).…”

Vinylimidazole coordination modes to Pt and Au metal centers

“…The high tendency to coordination to metal centers and formation of molecular complexes, as in the case of polymeric structures, is a source of diverse applications such as pharmacologically active species. 18,19 A survey of the CCDC database and literature reveals that exclusively nitrogen bound ligands are present in transition metal vinyl imidazole complexes. A quite large selection of complexes for lighter transition metals is published.…”

Alopecia Areata and Toxic Metals

“…This finding supports the suggestion that such zinc homeostasis imbalance is the underlying pathophysiologic mechanism for the development of alopecia areata. In our view, zinc depletion has an important role in the development of alopecia areata [10][11][12][13][14][15]. Therefore, alopecia areata can be attributed to an underlying, long-undiagnosed, zinc deficiency state [16,17].…”

“…Although specific markers of zinc deficiency have not been reported [15][16][17], we summarized the literature in Table 2. In our experience, biomarkers from blood samples -particularly when lowered initially -may be useful Twenty-five case subjects were determined using 1,376 individuals with adverse events to nonessential metal toxicants.…”

“…for clinical prediction of outcomes (Table 2). There is a risk of primary or secondary malabsorption states, both treatable with zinc repletion (mainly zinc sulfate, ZnSO 4 ), that should be considered [15][16][17]. About mercury, it is important to remember that all forms of mercury compounds (elemental, inorganic, and organic) are able to induce alopecia areata [5,18,19].…”