N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins

Rahimmi, Arman; Khosrobakhsh, Farnoosh; Izadpanah, Esmael; Moloudi, Mohammad Raman; Hassanzadeh, Kambiz

doi:10.1016/j.brainresbull.2015.02.007

Cited by 63 publications

(44 citation statements)

References 30 publications

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“…It is noted that NAC has been used with some success in clinical conditions and experimental models in which there are increases in brain oxidative stress (Halliwell, ), namely Alzheimer's disease (Adair et al., ; Pocernich and Butterfield, ), stroke/ischemia (Uemura et al., ), and Parkinson's disease (Monti et al., ; Rahimmi et al., ). In line with preclinical work (Quintanilla et al., ), a recent clinical study showed that NAC treatment significantly reduced alcohol intake in patients who had also consumed cannabis (Squeglia et al., ).…”

Section: Discussionmentioning

confidence: 99%

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Quintanilla

Morales

Ezquer

et al. 2018

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Quintanilla

Morales

Ezquer

et al. 2018

Alcoholism Clin & Exp Res

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“…6.1 | Drp1 and AD AD, the most common neurodegenerative disorders all over the world, is a progressive and age-dependent disease characterized by the long-term memory and cognitive function decline and changes in the patient personality and behavior. Currently, more than 36 million people older than 65-years old all over the world were diagnosed as having AD, causing it becomes a huge healthy concern in the society (Baek et al, 2017;Bell et al, 2018 (Filichia, Hoffer, Qi, & Luo, 2016;Rahimmi, Khosrobakhsh, Izadpanah, Moloudi, & Hassanzadeh, 2015;Rappold et al, 2014;Z. Zhang, Liu, Jiang, Zhai, & Xing, 2016;Zuo et al, 2014).…”

mentioning

confidence: 99%

Dynamin‐related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases

Huang

Xie

et al. 2018

Journal Cellular Physiology

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Mitochondria play a key role in the maintenance of neuronal function by continuously providing energy. Here, we will give a detailed review about the recent developments in regards to dynamin‐related protein 1 (Drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the Drp1 knockout induced mice embryonic death, the dysfunction of the Drp1‐dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between Drp1 and amyloid β (Aβ) in Alzheimer's disease (AD), the mutant Huntingtin (Htt) in Huntington's disease (HD), and the Drp1‐associated pathogenesis of other neurodegenerative diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Drp1 is required for mitochondrial division determining the size, shape, distribution, and remodeling as well as maintaining of mitochondrial integrity in mammalian cells. In addition, increasing reports indicate that the Drp1 is involved in some cellular events of neuronal cells causing some neural system dysfunctions and neurodegenerative diseases, including impaired mitochondrial dynamics, apoptosis, and several posttranslational modification induced increased mitochondrial divisions. Recent studies also revealed that the Drp1 can interact with Aβ, phosphorylated τ, and mutant Htt affecting the mitochondrial shape, size, distribution, axonal transportation, and energy production in the AD and HD neuronal cells. These changes can affect the health of mitochondria and the function of synapses causing neuronal injury and eventually leading to the dysfunction of memory, cognitive impairment, resting tremor, posture instability, involuntary movements, and progressive muscle atrophy and paralysis in patients.

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“…Activation of pro-death pathways mediated by caspases Yao and Wood, 2009;Hasegawa, 2010. Hampered mitochondrial dynamics, mitochondrial fission protein, Drp-1 increase Rahimmi et al, 2015;Yu et al, 2011. Mitochondrial Olney, 1990 Activation of pro-apoptotic proteins including caspases and other calcium regulatory proteins Olney, 1990;Hsieh et al, 2012. Induction of death cascades Olney, 1990;Armentero et al, 2006.…”

Section: Causative Factors Affected Signals Referencesmentioning

confidence: 97%

Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits

Dutta

Mohanakumar

2015

Neurochemistry International

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N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins

Cited by 63 publications

References 30 publications

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine

Dynamin‐related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases

Tea and Parkinson's disease: Constituents of tea synergize with antiparkinsonian drugs to provide better therapeutic benefits

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