N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model

Ersoy, Gülçı̇n Şahin; Eken, Meryem; Tal, Reshef; Öztekin, Deniz; Devranoğlu, Belgin; Kaygusuz, Ecmel; Çevik, Özge

doi:10.1016/j.rbmo.2016.03.009

Cited by 24 publications

(25 citation statements)

References 48 publications

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“…Sahin Ersoy et al compared the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue preservation by assessing ovarian reserve and oxidative stress markers following ovarian torsion/detorsion injury. They noted that NAC administration resulted in more preantral follicles and significantly higher AMH levels compared with enoxaparin treatment and I/R injury [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries

Melekoğlu

Çiftçi

Eraslan

et al. 2018

BioMed Research International

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Objective To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and histopathological scores. Methods Sixty healthy rats were randomly divided into six equal groups: control, I/R, I/R + CH (50 mg/kg/day), I/R + GA (100 mg/kg/day), CH (50 mg/kg/day), and GA (100 mg/kg/day). Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after CH and GA treatment. Results The antioxidant defense system parameters were significantly higher in the ovarian tissues of the I/R + CH and I/R + GA groups than in those of the I/R group. Serum follicle-stimulating hormone levels were significantly reduced, and serum anti-Müllerian hormone levels were significantly increased in rats treated with CH and GA compared with those in the I/R group. Additionally, the histopathological scores of the I/R + CH and I/R + GA groups were significantly improved compared with those of the I/R group. Conclusions The significant improvements in tissue oxidative stress parameters, serum hormone levels, and histological scores observed in this study indicate that treatment with CH or GA may be a conservative approach to prevent I/R injury in adnexal torsion cases after the ovarian detorsion procedure.

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Section: Discussionmentioning

confidence: 99%

The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries

Melekoğlu

Çiftçi

Eraslan

et al. 2018

BioMed Research International

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“…When the literature is examined, it is seen that there are decreases in the AMH levels after 3 or 6 hours of ovarian torsion followed by 3 hours, 24 hours or 7 days of reperfusion. It is seen that short-term or long-term I/R events affect AMH levels [20,31,34,35].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

et al. 2019

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Objectives: The aim of this study was to compare the effects of sildenafil, vardenafil and tadalafil in treatment for ischemia/reperfusion injury which is created experimentally in rat ovaries. Material and methods: For this study, 30 female Wistar albino rats were used, and the rats were separated randomly into five groups consisting of six rats each: normal, torsion-detorsion, torsion-detorsion + sildenafil 1.4 mg/kg, torsion-detorsion + vardenafil 1.7 mg/kg and torsion-detorsion + tadalafil 5.0 mg/kg. The agents were given intraperitoneally 30 minutes before detorsion. An ovarian torsion procedure was implemented in all other groups for 3 hours with the exception of the normal group. Then, a detorsion procedure was implemented to the groups for 3 hours. Results: The sildenafil and vardenafil treatments showed protective effect by preventing significant increase in inflammation parameters. (p = 0.058, 0.138). The tadalafil treatment was only protective for cellular degeneration (p = 0.140). The vardenafil treatment was protective for edema (p = 0.238), vascular congestion (p = 0.111), inflammation (p = 0.138) and cellular degeneration (p = 0.532). Sildenafil, vardenafil and tadalafil inhibited the increase of atretic follicle. AMH levels were statistically different between torsion and detorsion and vardenafil group (p = 0.004, 0.004), whereas tadalafil and sildenafil groups were similar to normal group (p = 0.108, 0.108). Conclusions: PDE inhibitors were found to be effective in reducing ovarian ischemia/reperfusion injury. Sildenafil and tadalafil seem to be more effective than the vardenafil in protecting the ovarian reserve.

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“…In an ovarian torsion experimental study using a TUNEL assay, Taskin et al ( 18 ) showed that apoptosis in ovarian tissue was reduced by 2-APB treatment. Sahin Ersoy et al ( 27 ) evaluated the effects of N-acetylcysteine and enoxaparin on ovarian I/R injury. Using a TUNEL assay, the authors demonstrated that both molecules reduced the number of apoptotic cells, and found that N-acetylcysteine provided greater reduction.…”

Section: Discussionmentioning

confidence: 99%

Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

Başer

Taşkın

Adalı

et al. 2018

J Turkish German Gynecol Assoc

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Objective:The aim of the present study was to evaluate the effects of progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through the evaluation of biochemical and histopathologic parameters.Material and Methods:Twenty-one female Wistar albino rats were divided into three groups. Group 1: Sham; group 2: I/R; group 3: I/R+PG (8 mg/kg). PG was administered intraperitoneally to the rats in group 3, 30 minutes before a detorsion operation. Ovarian I/R injury was evaluated in serum and tissue by using biochemical parameters including malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, neutrophil gelatinase-associated lipocalin (NGAL) and immunofluorescence staining by using a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay.Results:Serum and tissue TOS levels were significantly lower in group 3 than in group 2. Tissue TAS levels were higher in group 3 than in group 2 (p<0.001). NGAL and MDA levels were similar between the groups. Histologic score, including vascular congestion, hemorrhage, polymorphonuclear neutrophils, and interstitial edema, was higher in group 2. Pre-treatment with PG decreased the score, but this difference was not statistically significant. The number of apoptotic cells was higher in group 2 than in groups 1 and 3. The TUNEL-positive cell number decreased with PG in group 3.Conclusion:Preoperative PG treatment might exert protective effects on ovarian I/R injury through its anti-apoptotic and antioxidative properties.

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N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model

Cited by 24 publications

References 48 publications

The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries

The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

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