N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists

Christensen, Peter M.; Bangsbo, Jens

doi:10.1007/s00421-019-04132-7

Cited by 7 publications

(36 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 1 summarizes the data from the studies presented in Table 1 showing the potential effects of NAC on mito-and sarcohormesis under exercise-induced oxidative stress. Exercise at different intensities, such as muscle-damaging [13,82,84,93,94,97], fatigue-inducing [17,68,73,74,80,83,88,90,95,96,100], high-intensity [87,101], and repetitive intermittent exercises [81,86,89], cause excessive accumulation of ROS in the body. NAC supplementation can provide several advantages for maintaining mitohormesis by increasing endogenous antioxidant defense, suppressing pro-oxidants, and upregulating cytoprotective adaptations [71,73,74,85,98,99].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, NAC studies have conducted on recreationally trained individuals, endurance trained men, and athletes. Three studies investigating the effect of NAC on sarcohormesis in the athletic population did not confirm NAC-induced sarcohormesis in athletes [99][100][101]. Two of these studies argued that NAC supplementation had no effect on sarcohormesis [99,100], while one reported that it negatively affected ROS-induced metabolic adaptations in skeletal muscle [101].…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, another study on the interaction between NAC supplementation and K + -regulation in plasma during exercise revealed that NAC led to an increase in the K + -to-work ratio, indicating that NAC impaired the K + -regulation during intense, intermittent exercise, thereby declining exercise performance [69]. In addition to that, one study on well-trained cyclists found that NAC supplementation before an repeated intense endurance cycling performance did not affect plasma K +concentrations [100]. Collectively, further research is urgently needed to clarify the possible contributions of NAC on K + -regulation.…”

Section: Possible Part Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Skeletal Muscle To Exercisementioning

confidence: 99%

“…NAC supplementation was administered to several specific groups of athletes, including cyclists [100,101], triathletes [73], rowers [99], and volleyball players [98] to determine their role in redox related changes. Researchers also evaluated the possible effects of NAC on exercise-induced oxidative stress and adaptive mechanisms in healthy untrained men [68][69][70]72,74,[80][81][82][83][84], recreationally trained men [13,74,[85][86][87][88][89][90][91][92], and endurance-trained men [17,[94][95][96].…”

Section: Possible Role Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Mitochondria To Exercisementioning

confidence: 99%

“…NAC is thought to be effective in modulating K + homeostasis during ROS-mediated degradation [88]. However, NAC studies on K regulations presented equivocal results [69,88,95,100]. One study sought to evaluate the role of NAC on muscle Na + -K + -pump activity during submaximal cycling exercise in endurance-trained men [95].…”

Section: Possible Part Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Skeletal Muscle To Exercisementioning

confidence: 99%

See 4 more Smart Citations

How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

2021

View full text Add to dashboard Cite

Exercise frequently alters the metabolic processes of oxidative metabolism in athletes, including exposure to extreme reactive oxygen species impairing exercise performance. Therefore, both researchers and athletes have been consistently investigating the possible strategies to improve metabolic adaptations to exercise-induced oxidative stress. N-acetylcysteine (NAC) has been applied as a therapeutic agent in treating many diseases in humans due to its precursory role in the production of hepatic glutathione, a natural antioxidant. Several studies have investigated NAC’s possible therapeutic role in oxidative metabolism and adaptive response to exercise in the athletic population. However, still conflicting questions regarding NAC supplementation need to be clarified. This narrative review aims to re-evaluate the metabolic effects of NAC on exercise-induced oxidative stress and adaptive response developed by athletes against the exercise, especially mitohormetic and sarcohormetic response.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Possible Part Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Skeletal Muscle To Exercisementioning

confidence: 99%

Section: Possible Role Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Mitochondria To Exercisementioning

confidence: 99%

Section: Possible Part Of N-acetylcysteine During the Regulation Of Oxidative Stress Response Of Skeletal Muscle To Exercisementioning

confidence: 99%

See 3 more Smart Citations

How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

2021

View full text Add to dashboard Cite

show abstract

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments

McKenna,

Renaud,

Ørtenblad

et al. 2024

Eur J Appl Physiol

View full text Add to dashboard Cite

This historical review traces key discoveries regarding K+ and Na+ ions in skeletal muscle at rest and with exercise, including contents and concentrations, Na+,K+-ATPase (NKA) and exercise effects on plasma [K+] in humans. Following initial measures in 1896 of muscle contents in various species, including humans, electrical stimulation of animal muscle showed K+ loss and gains in Na+, Cl− and H20, then subsequently bidirectional muscle K+ and Na+ fluxes. After NKA discovery in 1957, methods were developed to quantify muscle NKA activity via rates of ATP hydrolysis, Na+/K+ radioisotope fluxes, [3H]-ouabain binding and phosphatase activity. Since then, it became clear that NKA plays a central role in Na+/K+ homeostasis and that NKA content and activity are regulated by muscle contractions and numerous hormones. During intense exercise in humans, muscle intracellular [K+] falls by 21 mM (range − 13 to − 39 mM), interstitial [K+] increases to 12–13 mM, and plasma [K+] rises to 6–8 mM, whilst post-exercise plasma [K+] falls rapidly, reflecting increased muscle NKA activity. Contractions were shown to increase NKA activity in proportion to activation frequency in animal intact muscle preparations. In human muscle, [3H]-ouabain-binding content fully quantifies NKA content, whilst the method mainly detects α2 isoforms in rats. Acute or chronic exercise affects human muscle K+, NKA content, activity, isoforms and phospholemman (FXYD1). Numerous hormones, pharmacological and dietary interventions, altered acid–base or redox states, exercise training and physical inactivity modulate plasma [K+] during exercise. Finally, historical research approaches largely excluded female participants and typically used very small sample sizes.

show abstract

“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance”. Acute antioxidant supplementation and performance – should this be considered

Larsen

2024

Free Radical Biology and Medicine

View full text Add to dashboard Cite

N-Acetyl cysteine does not improve repeated intense endurance cycling performance of well-trained cyclists

Cited by 7 publications

References 31 publications

How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments

“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance”. Acute antioxidant supplementation and performance – should this be considered

Contact Info

Product

Resources

About