N-3 Long-Chain Polyunsaturated Fatty Acids Prevent Excessive Fat Deposition in Adulthood in a Mouse Model of Postnatal Nutritional Programming

Oosting, Annemarie; Kegler, Diane; Boehm, Günther; Jansen, Harm T.; Heijning, Bert J. M. van de; Beek, Eline M. van der

doi:10.1203/pdr.0b013e3181f74940

Cited by 38 publications

(45 citation statements)

References 40 publications

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“…In addition, n3 long-chain polyunsaturated fatty acid supplementation during pregnancy and lactation reduced BW of adult rat offspring on a standard chow by 5% (28). In accordance, we have shown previously that 5% n3 long-chain polyunsaturated fatty acids in the postnatal diet of mice lowers adult FM by 28% upon 56 d of WSD feeding (18). The magnitude of this nutritional programming effect on adult FM closely resembles that of our present study, which investigated a postnatal diet with distinct physical and compositional lipid properties without any significant change in FA composition.…”

Section: Discussionsupporting

confidence: 92%

“…To test this hypothesis, we developed a concept IMF with lipid droplets with physical properties similar to those in HM, i.e., larger in size and coated with PLs (Nuturis; Danone Research, Paris, France). We compared this concept IMF with a control IMF in a mouse model of nutritional programming (18). A diet containing either control or concept IMF was provided…”

mentioning

confidence: 99%

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Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood

Oosting¹,

Kegler²,

Wopereis

et al. 2012

Pediatr Res

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Background: In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipidcoated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life. Methods: Male c57Bl/6j mice were fed a control formula (control IMF) or Nuturis (concept IMF) diet between postnatal day (PN)16 and PN42. all mice were subsequently fed a Western-style diet (WsD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126. results: concept IMF slightly increased lean body mass as compared with control IMF at PN42 but did not affect fat mass. Upon 84 d of WsD feeding, the concept IMF group showed reduced fat accumulation as compared with control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the concept IMF group. conclusion: Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood

Oosting¹,

Kegler²,

Wopereis

et al. 2012

Pediatr Res

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“…These observations showed that ARA via metabolism of LA was a key determinant in fat mass and globally underlined that LA/LNA ratios during perinatal period could have important programming effect on body composition (Ailhaud et al, 2006). Further proofs of evidence of lipids being involved in programming other functions were obtained in 2010 in animal models (rodents) by two research groups (Innis et al, 2010;Oosting et al, 2010). These results were obtained on non-dairy lipids but paved the way for further investigations on 'dairy lipid structure and programming' conducted just after by Oosting et al (2011Oosting et al ( , 2012Oosting et al ( , 2014.…”

Section: Introductionmentioning

confidence: 90%

“…At the same time, Oosting et al (2010) investigating further Ailhaud's group hypothesis (Ailhaud et al, 2006), established still in a rodent model, that n-3 LCPUFA-rich neonatal diet programmed adult body composition (reduction of 30% fat accumulation during western style diet challenge) and metabolic homeostasis. Healthier plasma lipid profile, plasma glucose parameters and less adipocytes hypertrophy were observed in the group of mice that had received the n-3 enriched diet during neonatal period.…”

Section: 1mentioning

confidence: 99%

“…Healthier plasma lipid profile, plasma glucose parameters and less adipocytes hypertrophy were observed in the group of mice that had received the n-3 enriched diet during neonatal period. Oosting et al (2010) set the hypothesis that unbalanced n-6/n-3 neonatal intake favoured LA conversion to ARA and its eicosanoids metabolites. These metabolites may directly stimulate adipogenesis through activation of peroxisome proliferator-activated receptor delta and gamma.…”

Section: 1mentioning

confidence: 99%

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Towards infant formula biomimetic of human milk structure and digestive behaviour

Bourlieu-Lacanal

Deglaire

Oliveira

et al. 2017

OCL

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-Lipids of human milk or infant formula convey most of the energy necessary to support the newborn growth. Until recently, infant formula chemical composition had been optimized but not their structure. And yet, more and more proofs of evidence have shown that lipids structure in human milk modulates digestion kinetics and is involved in metabolic programming. Indeed there is a striking difference of structure between human milk which is an emulsion based on dispersed milk fat globules (4 mm) secreted by the mammary gland and submicronic neoformed lipid droplets (0.5 mm) found in infant formula. These droplets result from a series of operation units. This difference of structure modifies digestion kinetics and emulsion disintegration in the intestinal tract of the newborn. This difference persists along gastric phase which is mainly dominated by acid and enzyme-induced aggregation. Lipid droplets size is thus the key parameter to control gastric lipolysis and emptying and intestinal lipolysis. This parameter also controls proteolysis since adsorbed proteins are more rapidly hydrolyzed than when in solution. In animal models, these differences of lipid structure would also impact digestive and immune systems' maturation and microbiota. Lipid structure during neonatal period would also be involved in the early programming of adipose tissues and metabolism. The supplementation of infant formulas with bovine milk fractions (milk fat globule membrane extracts, triacylglycerol) or recent development of large droplets infant formula, along with new fields of innovation in neonatal nutrition, are here reviewed.Keywords: human milk fat globules / lipid structure / infant formula / neonatal digestion / programming Résumé -Vers des formules infantiles mimant la structure et le profil de digestion du lait maternel.Les lipides laitiers du lait maternel ou de formules infantiles fournissent la plupart de l'énergie disponible pour la croissance du nouveau-né. Jusqu'alors, la composition chimique des formules infantiles a été optimisée mais pas leur structure. Or il est de plus en plus démontré que la structure des lipides dans le lait maternel module les cinétiques de digestion et participe à la pré-programmation métabolique. Il existe en effet une différence majeure entre les émulsions natives de globules gras laitiers (4 mm) sécrétées par la glande mammaire et la structure des lipides dans les formules infantiles qui résultent d'une succession d'opérations unitaires de transformation et sont constituées de gouttelettes submicroniques (0.5 mm) avec des interfaces néoformées. Cette différence de structure modifie les cinétiques de digestion et de déstructuration des émulsions dans le tractus digestif des nouveau-nés. De façon générale, la différence de structure initiale entre lait maternel et formules infantiles se maintient pendant toute la phase gastrique, qui est surtout dominée par des mécanismes d'agrégation acide et enzymatique. La taille des gouttelettes est le paramètre clé pour contrôler les lipolyses gastri...

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Arachidonic acid/docosahexaenoic acid‐supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice

Wielinga¹,

Harthoorn

Verschuren³

et al. 2012

Molecular Nutrition Food Res

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Scope: This study addresses whether early life arachidonic acid (ARA)/docosahexaenoic acid (DHA) supplementation or eicosapentaenoic acid (EPA)/DHA (Omacor) supplementation affects body weight gain, lipid metabolism, and adipose tissue quantity and quality in later life in ApoE*3Leiden-transgenic mice, a humanized model for hyperlipidemia and mild obesity. Methods and results: Four-week-old male ApoE*3Leiden mice were fed chow diet with or without a mixture of ARA (0.129 wt%) and DHA (0.088 wt%) or Omacor (0.30 wt% EPA, 0.25 wt% DHA). At age 12 weeks, mice were fed high-fat/high-carbohydrate (HFHC) diet without above supplements until age 20 weeks. Control mice received chow diet throughout the study. Mice receiving ARA/DHA gained less body weight compared to control and this effect was sustained when fed HFHC. Omacor had no significant effect on body weight gain. Plasma cholesterol and triglycerides were significantly lowered by both supplementations. At 20 weeks, epididymal fat mass was less in ARA/DHA-supplemented mice, while Omacor had no significant effect on fat mass. Both ARA/DHA and Omacor reduced inguinal adipocyte cell size; only ARA/DHA significantly reduced epididymal macrophage infiltration. Conclusion: This study shows that early life ARA/DHA, but not Omacor supplementation improves body weight gain later in life. ARA/DHA and to a lesser extent Omacor both improved adipose tissue quality.

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N-3 Long-Chain Polyunsaturated Fatty Acids Prevent Excessive Fat Deposition in Adulthood in a Mouse Model of Postnatal Nutritional Programming

Cited by 38 publications

References 40 publications

Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood

Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood

Towards infant formula biomimetic of human milk structure and digestive behaviour

Arachidonic acid/docosahexaenoic acid‐supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice

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