Myxoid tumours of soft tissue

Roggen, J. Frans Graadt van; Hogendoorn, Pancras C.W.; Fletcher, Christopher D.�M.

doi:10.1046/j.1365-2559.1999.00835.x

Cited by 212 publications

(194 citation statements)

References 79 publications

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“…The myxomatous type generates large amounts of myxoid matrix and is typically immunoreactive to the S-100 protein (1-3,8). The cellular type contains little myxoid material and shows no immunoreactivity to the S-100 protein (5). Neurothekeoma cells are usually spindle-shaped and arranged in fascicular or whorled patterns.…”

Section: Discussionmentioning

confidence: 99%

Characterization of an intracranial neurothekeoma: case report

Yavuz

Köktekir²,

Bayar³

et al. 2010

Turkish Neurosurgery

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AIm: Neurothekeomas are benign tumors of presumed neural sheath origin. They are primarily found in superficial soft tissues, located in the upper portion of the body. Here, we report a case of intracranial neurothekeoma. results:A 37-year-old female presented at our clinic with sudden-onset left hemifacial pain of varying duration. The physical and neurological examination findings were normal. The magnetic resonance imaging scan showed a mass compressing the pons and extending from the medial section of the left middle fossa to the posterior fossa. The patient was operated on using a left presigmoid transpetrosal approach and the mass was totally removed.COnClusIOn: Neurothekeomas, also known as nerve sheath myxomas, are rare benign tumors. There have been two previous cases reported with an intracranial location. The information presented here now represents the third such case in the literature. KeywOrds: Brain tumor, Intracranial, Nerve sheath myxoma, Neurothekeoma ÖZAmAÇ: Nörotekomalar nöral kılıf orjinli iyi huylu tümörlerdir. Genellikle gövdenin üst kısımlarındaki yüzeyel dokularda rastlanır. Biz burada bir intrakranial nörotekoma vakasını sunuyoruz.BulGulAr: 37 yaşında kadın hasta kliniğimize, yüzünün sol yarısında ani başlayan ağrı şikayeti ile başvurdu. Fizik ve nörolojik muayene bulguları normaldi. Kranial MR da sol orta kranial fossadan posterior fossaya doğru uzanan ponsa bası yapan kitle saptandı. Hasta sol presigmoid transpetrosal yaklaşımla opere edildi ve kitle tamamen çıkartıldı. sOnuÇ: Nörotekomalar, diğer bilinen adıyla sinir kılıfı miksomaları, iyi huylu tümörlerdir. Literatürde intrakranial lokalizasyonda bildirilen 2 vaka vardır ve biz burada 3. vakayı sunuyoruz.

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Section: Discussionmentioning

confidence: 99%

Characterization of an intracranial neurothekeoma: case report

Yavuz

Köktekir²,

Bayar³

et al. 2010

Turkish Neurosurgery

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“…The differential diagnoses of myxofibrosarcoma include other myxoid tumours often hard to distinguish from each other, since differences are often very subtle. 12 However, the distinction between all these myxoid subtypes is truly important from a clinical point of view, both for required therapy as for follow-up. Therefore, the existence of a specific (cyto) genetic aberration could serve as a welcome diagnostic marker and a helpful tool to distinguish these subtypes.…”

Section: Discussionmentioning

confidence: 99%

Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model

et al. 2006

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Myxofibrosarcoma is one of the most frequent soft tissue tumours in elderly patients, mostly arising in the extremities. Grade I lesions are only locally aggressive whereas grade II and grade III lesions have metastatic potential. The differential diagnosis contains several other (benign) myxoid soft tissue tumours. A number of sarcomas are characterised by specific cytogenetic aberrations, giving not only insight in their biological pathways; they also serve as molecular markers in difficult diagnoses. Cytogenetic data on myxofibrosarcoma are scarce with only few isolated cases described in the literature. No specific chromosomal aberrations have been detected so far. Moreover, molecular pathways in tumorigenesis and progression of myxofibrosarcoma are barely understood. We studied the clinicopathologic data and karyotypes of 32 myxofibrosarcomas using conventional banding and multicolour COmbined Binary RAtio labelling fluorescence in situ hybridisation technique. We included eight grade I, eight grade II and 16 grade III lesions. In all, 22 were primary tumours, nine were local recurrences and one a lymph node metastasis. The myxofibrosarcomas showed equal sex distribution, were mostly located at the extremities with two thirds deep-seated and had an average age of occurrence of 66 years. We found normal karyotypes in eight cases and clonal beside nonclonal aberrations in 22 cases. Complex cytogenetic anomalies were found in all grades. However, no tumour-specific chromosomal abnormalities could be withdrawn. Local recurrences showed increase in grade compared to their primary lesions. Interestingly, these recurrences showed more complex cytogenetic aberrations. Increase in grade seems to parallel increase in cytogenetic aberrations and malignant potential. Since the chromosomal aberrations found were not tumour type specific, they seem to be rather the result of secondary events in tumour progression and tumour genetic instability. Based on these findings, we suggest that tumorigenesis of myxofibrosarcoma is mainly a multistep genetic process, probably ruled by genetic instability caused by targeted checkpoint genes.

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“…Myxoid DFSP is a rare variant of this neoplasm, characterized by prominent myxoid stromal changes. The first such case was cited in 1983 by Frierson and Cooper [4]. Since then only a few cases have been reported.…”

Section: Case Reportmentioning

confidence: 99%

Myxoid Dermatofibrosarcoma Protuberans of the vulva with myoid nodules: Clinicopathologic and Immunohistochemical study of a case

Vasudevan¹,

Singhania²,

Shivamurthy³

2013

Our Dermatol Online

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Dermatofibrosarcoma protuberans is a slow growing dermal spindle cell tumor seldom seen in the vulva and its myxoid variant, a rare type of dermatofibrosarcoma protuberans is characterised by extensive myxoid degeneration. We present the case of a 62 year old woman with an enlarging vulval swelling. Mass was excised surgically. Histopathologically the tumor consisted of uniform spindle-shaped cells showing strong positivity with CD34. In addition to the typical storiform pattern and lace like infiltration, prominent myxoid stromal changes were seen. Herein we report an interesting case of myxoid dermatofibrosarcoma protuberans, uncommonly reported in the dermatopathology literature.

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Myxoid tumours of soft tissue

Cited by 212 publications

References 79 publications

Characterization of an intracranial neurothekeoma: case report

Characterization of an intracranial neurothekeoma: case report

Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model

Myxoid Dermatofibrosarcoma Protuberans of the vulva with myoid nodules: Clinicopathologic and Immunohistochemical study of a case

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