Characterization of an intracranial neurothekeoma: case report

Yavuz, Erdem; Köktekir, Ender; Bayar, Mehmet Akif; Yılmaz, Ali; Çaydere, Muzaffer

doi:10.5137/1019-5149.jtn.3099-10.2

Cited by 6 publications

(9 citation statements)

References 15 publications

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“…Based on statistical analysis, GTR alone, if tolerable, is advocated as the optimal treatment for PICM. 6,39 Nevertheless, conservative excision may be preferred to avoid damage to vital structures. 22 PICMs have a tendency to recur within a few years of the initial surgery if resection is incomplete; therefore, postoperative follow-up is essential.…”

Section: Discussionmentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

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OBJECTIVEPrimary intracranial myxomas (PICMs) are extremely rare neoplasms, and their management and prognostic factors remain ambiguous. The authors aimed to elaborate the radiological features, evaluate the risk factors for progression-free survival (PFS), and propose a treatment protocol based on pooled data from cases treated at their institute and those found in the literature.METHODSClinical data from all cases of PICMs treated at the authors’ institute and those cases reported in the English-language literature between 1987 and December 2017 were reviewed. The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords “myxoma” and “central nervous system,” “intracranial,” “cerebral,” “skull base,” “skull,” or “brain.” Previously published data were processed and used according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Risk factors in the pooled cohort were evaluated.RESULTSCases from the authors’ institute included 21 males and 9 females, with a mean age of 35.7 ± 1.7 years. Gross-total resection (GTR) and non-GTR were achieved in 6 (20.0%) and 24 (80.0%) patients, respectively. After a mean follow-up of 86.7 ± 14.1 months, recurrence occurred in 6 (24%) patients, for a median PFS time of 85.2 months (range 36.0–136.0 months) and no deaths. In the literature between 1987 and 2017, 35 cases of PICM were identified in 14 males and 21 females with a mean age of 31.7 ± 3.2 years. GTR and non-GTR were achieved in 23 (65.7%) and 9 (25.7%) cases, respectively. After a mean follow-up of 25.8 ± 6.9 months (range 1.0–156.0 months), recurrence occurred in 4 (14.3%) patients, for a median PFS time of 11.0 months (range 3.0–36.0 months) and no deaths. Actuarial PFS rates at 1, 5, and 10 years were 93.0%, 80.6%, and 67.9%, respectively. A multivariate model demonstrated that GTR (HR 0.058, 95% CI 0.005–0.680, p = 0.023) was the only factor that favored PFS.CONCLUSIONSPICMs are rare neoplasms with a slightly higher occurrence in males. GTR was the only favorable factor for PFS. Based on statistical results, GTR alone, if tolerable, is advocated as the optimal treatment for PICM. Nevertheless, conservative excision may be preferred to avoid damage to vital structures. PICMs have a tendency to recur within a few years of the initial surgery if resection is incomplete; therefore, close postoperative follow-up is mandatory. Future studies with larger cohorts are necessary to verify the study findings.Systematic review registration no.: CRD42018091517 (www.crd.york.ac.uk/prospero/)

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Section: Discussionmentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

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“…[4][5][6] Neurothekeoma is often seen in the head and neck skin of children and young adults. 2 These tumors are more common in females. 3 Based on the incidence of myxoid stroma, neurothekeoma are divided into myxoid, cellular and mixed subtypes.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal neurothekeoma: A rare tumor

Sayan

Çelik

Ertunç

et al. 2014

Asian Cardiovasc Thorac Ann

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Neurothekeoma, also known as nerve sheath myxoma, is a benign nerve sheath tumor that usually arises in the cutaneous nerves of the head, neck, or upper extremities. Extracutaneous placement is very rare. Mediastinal neurothekeoma has not previously been reported in the English literature. A 30-year-old woman was admitted to our clinic with back pain. A smooth-edged mass found in her paravertebral region, and a neurogenic tumor was suspected. The tumor was completely excised. Final pathology revealed it to be a mediastinal neurothekeoma.

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“…Neurothekeoma is nothing but a benign nerve sheath tumor with extensive myxoid degeneration that commonly arises from small cutaneous nerves and has a predilection for the head, neck and shoulders. [17] Until date only four cases of intracranial neurothekeomas (all extraosseous) have been reported, located in the prepontine cistern, [18] posterior fossa, [19] parasellar region [20] and deep white matter in the middle cranial fossa. [21] All these cases showed predominant T1 hypointensity and T2 hyperintensity with heterogeneous post-contrast enhancement.…”

Section: Discussionmentioning

confidence: 99%