Myxoid Liposarcoma with Cartilagenous Differentiation

Abstract

Myxoid liposarcoma (MLPS) is an adipocytic tumour and second commonest among the types of liposarcoma. It exhibits a wide histological spectrum. It is important to be aware of this diversity of morphology in this tumour to prevent a wrong diagnosis. Heterologous differentiation in myxoid liposarcoma is reported; however, this is rare. To date, seven cases of MLPS with cartilaginous differentiation have been reported. Only five of these were further confirmed by cytogenetic analysis. We are reporting the 8th case of MLPS with cartilaginous differentiation. A 66-year female presented with posterior left thigh mass. Excision was done. Microscopic examination showed sheets of bland spindle cells containing round to oval nuclei and fine, delicate chicken-wire vessels. The firm blue appearing areas, which accounted for about 20% of the tumor volume, were characterised by mature hyaline cartilage. The final diagnosis was MLPS, showing prominent cartilaginous differentiation. Anterior and lateral margins were involved. Tumour was very close to the rest of the resection margins. FNCLCC grade was 1. Provisional pathological stage, as per staging system of the Union for International Cancer Control for extremity, was pT2. Patient was examined by oncologists. Wide local excision is in plan as two margins were involved by the tumour, while rest of the margins were very close to tumour.

Extraskeletal myxoid chondrosarcoma of the gingival: a rare case report and review of the literature

“…7 B). KRT19 positivity observed in some of cases confirm the occurrence of odontogenic epithelial remnants [ 24 ], which may be in favor of the diagnosis.

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The Conundrum of Dedifferentiation in a Liposarcoma at a Peculiar Location: A Case Report and Literature Review

“…Regarding the challenging histopathologic features of some liposarcomas which may lead to a misinterpreted diagnosis, the question of heterologous differentiation and tumour metaplasia has also been put [ 19 ] Heterologous differentiation within a myxoid liposarcoma has only rarely been reported [ 20 , 21 ]. The main discussion in this matter refers to the morphology of the proliferated heterologous elements which may highly resemble tumour metaplasia [ 19 ].…”

“…The main discussion in this matter refers to the morphology of the proliferated heterologous elements which may highly resemble tumour metaplasia [ 19 ]. Up to date, five cases of myxoid liposarcoma with cartilaginous differentiation confirmed on cytogenetic analysis have been reported [ 20 ]. In our case, the proliferation displayed an abrupt transition towards a non-lipogenic area composed of pleomorphic spindle cells with unequivocal malignant features, ruling out metaplasia.…”

The Immune Contexture of Liposarcoma and Its Clinical Implications

“…MLPS accounts for approximately 30% of all LPS [ 2 , 4 , 42 , 43 ]. Unlike the other subtypes, it usually affects younger individuals between 30–50 years of age [ 2 , 43 ]. However, MLPS can also occur during childhood and adolescence [ 2 , 4 , 42 , 43 ].…”

“…Unlike the other subtypes, it usually affects younger individuals between 30–50 years of age [ 2 , 43 ]. However, MLPS can also occur during childhood and adolescence [ 2 , 4 , 42 , 43 ]. Typically, it originates in the proximal extremities with almost 75% of cases occurring in the thigh [ 4 , 42 ].…”