Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients

Dürr, Hans Roland; Rauh, Jessica L.; Baur‐Melnyk, Andrea; Knösel, Thomas; Линднер, Ларс; Roeder, Falk; Jansson, Volkmar; Klein, Alexander

doi:10.1186/s12885-018-4226-8

Cited by 65 publications

(61 citation statements)

References 31 publications

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“…Round cell liposarcoma is recognized as a high‐grade, cell‐specific variant of MLPS characterized by poor prognosis. Local recurrence and metastasis to atypical sites, such as bone, retroperitoneum, or lymph nodes, are also commonly encountered. The treatment options for soft tissue sarcoma consist of tumor resection, neoadjuvant chemotherapy, adjuvant chemotherapy, and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Zheng¹,

Yu²,

Xu³

et al. 2019

Orthopaedic Surgery

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ObjectivesTo evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities.MethodsWe retrospectively reviewed 34 patients histologically diagnosed with myxoid liposarcoma arising in the extremities, treated in our hospital from 2010 to 2017. We recorded tumor locations, max diameter, operations, complications, radiation, chemotherapy, survival, recrudescence, and metastases. Overall survival, treatments, and prognostic factors were subsequently analyzed.ResultsThe mean age of 34 patients with myxoid liposarcoma in extremities was 49.1 years, and the mean follow‐up period was 65.1 months. The median survival time was 190 months. Five of 14 patients accepted recrudescence resection and two patients of 20 patients who underwent primary tumor resection or unplanned operation died of tumor progression. Although no statistical difference was found (X 2 = 3.331, P = 0.068), the lower mortality was confirmed in the patients who accepted primary tumor resection or unplanned operation. Eleven patients with a tumor diameter of 8.6 ± 4.7 cm accepted wide resection, while 23 patients with 17.2 ± 8.8 cm tumors accepted marginal resection. Statistical difference was found between the size of tumors with relatively wide resection and those with relatively marginal resection (F = 9.130, P = 0.005). No recurrence or metastasis occurred in patients who accepted wide resection, while 14 patients presented with local recurrence and 8 patients developed distant metastases among the 23 patients with marginal resection. Seven patients died of metastases, while one patient lived with metastases. No significant difference in survival was found between different surgical methods (X 2 = 0.9460, P = 0.3307). The average diameter of eight patients with distant metastases was 21.7 cm, which was considerable larger than the 12.1 cm of patients without metastasis. This difference was proven significant upon the statistical analysis (F = 9.412, P = 0.004).ConclusionsWide resection achieved good local control but was not unambiguously superior in long‐term survival. Myxoid liposarcoma tumors with larger diameters were more difficult to be submitted to wide resection and were more likely to present with distant metastasis.

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Section: Introductionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Zheng¹,

Yu²,

Xu³

et al. 2019

Orthopaedic Surgery

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“…The clinical symptoms reported were principally abdominal pain and distention, both in the present cohort and in that previously published ones. [9,[24][25][26] Since abdominal pain and distention were nonspeci c and tolerable to patients, it was di cult to diagnose retroperitoneal LPS or differentiate subtypes of LPS via clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…MLPS often shows multilobulated, hypoechoic structure on ultrasound [28]. Moreover, MLS usually exhibits low signal intensity in T1W and intermediate signal intensity in T2W, making it recognizable with other types of tumors [12,25]. PLPS, due to its special component, shows little fat attenuation on CT [14].…”

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confidence: 99%

Diagnosis and Prognosis of Retroperitoneum Liposarcoma: a single Asian center cohort of 57 cases

Liu

Xiao

2020

Preprint

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Background Liposarcoma is a form of malignancy found in soft tissues, mostly observed in the extremities. However, retroperitoneum liposarcoma has been seldom reported, and such diagnosis is also neglected. This study aims to present the clinical characteristics, diagnosis and prognosis of 5 different subtypes of liposarcoma and report our experience of treatment of the patients. Methods We conducted a single-center non-intervention retrospective study of 57 retroperitoneal liposarcoma patients who were admitted to Peking Union Medical College Hospital (PUMCH, Beijing, China) from December 2007 to May 2018. We collected and analyzed the demographic, clinical, imaging, histologic, therapeutic and prognostic data for these patients over a mean 4.5-year follow up period. Results Twenty-five (44%) patients were asymptomatic prior to diagnosis, with abdominal distension as the chief complaint for 18 (32%) patients and abdominal pain observed in 16 (28%) patients. Masses were evaluated by CT (n=48, 84%) or ultrasound (n=25, 44%). Laparotomy (n=52, 91%) was the preferred dominant therapeutic modality rather than laparoscopy (n=5, 9%). All patients were treated with R0 resection except 2 patients who underwent R2 resection. We conducted regular follow-up every 6 months after surgery for a mean duration of 4.5 years. Recurrence was experienced by 15 (26%) patients and a further 11 (19%) died during follow up. Conclusions Abdominal distension and pain are main chief complaints of liposarcoma. As extremity is the main location for liposarcoma occurrence, diagnosis of retroperitoneum liposarcoma is usually neglected. Since half of the patients are asymptomatic, timely diagnosis and treatment are highly dependent on regular ultrasound and CT imaging. R0 resection is the key to retroperitoneal liposarcoma treatment. Comparingly, patients underwent R2 resection, which is considered as a palliative treatment, have bad prognosis. Dedifferentiated liposarcoma, especially those with organ invasion, tend to have bad prognosis, and prognosis for well-differentiated or myxoid liposarcoma is relatively good.

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“…Adjuvant radiotherapy is the standard treatment of high-grade (G2–3) sarcomas [ 4 ] and mostly recommended in lesions >5 cm, especially when locallized deeply.…”

Section: Discussionmentioning

confidence: 99%

Giant myxoid liposarcoma of the gluteal region: case report of patient caused delay of surgical treatment and review of the literature

Willburger

Kettelhack

Fuchs

et al. 2018

Journal of Surgical Case Reports

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Although adult soft tissue sarcoma is a rare disease, it needs individual treatment by an experienced, interdisciplinary team. We present an exceptional case of a 36-year-old woman suffering from a giant intermediate grade myxoid liposarcoma of the left buttock. She had been seen 4 years earlier but refused to undergo any treatment by then. Now suffering from a foul, ulcerating and superinfected tumor she agreed to surgical treatment. Despite delay, treatment could be performed according to the most up to date sarcoma guidelines which are discussed, including a brief review of the literature.

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Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients

Cited by 65 publications

References 31 publications

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Diagnosis and Prognosis of Retroperitoneum Liposarcoma: a single Asian center cohort of 57 cases

Giant myxoid liposarcoma of the gluteal region: case report of patient caused delay of surgical treatment and review of the literature

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