Myxoglobulosis of the Appendix: A Case Associated with Ruptured Diverticulum

Aroukatos, Panagiotis; Verras, Dionysios; Vandoros, Gerassimos P.; Repanti, Maria

doi:10.1155/2010/745021

Cited by 6 publications

(7 citation statements)

References 5 publications

(9 reference statements)

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“…Myxoglobulosis is a subtype of AMN, in which the appendiceal lumen is full of white globules that look like frog eggs. Factors affecting the occurrence of myxoglobulosis include proximal appendiceal obstruction and mucosal secretion at the residual appendiceal mucosa; in addition, some studies have reported myxoglobulosis to be associated with persistent chronic inflammation [9–11].…”

Section: Discussionmentioning

confidence: 99%

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Appendiceal mucinous neoplasm with myxoglobulosis occurring 3 years after perforated barium appendicitis: a case report

et al. 2019

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Background Myxoglobulosis is considered a subtype of appendiceal mucinous neoplasm (AMN). Factors affecting the occurrence of myxoglobulosis include proximal appendiceal obstruction and mucosal secretion at the residual appendiceal mucosa. In addition, myxoglobulosis has also been reportedly associated with persistent chronic inflammation. We report a case of AMN with myxoglobulosis occurring 3 years after perforated barium appendicitis and the importance of caution during surgery for barium peritonitis and elucidate the pathology of myxoglobulosis. Case presentation A 45-year-old man with an AMN underwent laparoscopic ileocecal resection 3 years after peritonitis caused by perforated barium appendicitis. The patient had a medical history of perforated barium appendicitis after barium swallow imaging, which was treated conservatively 3 years ago. Computed tomography (CT) revealed cystic enlargement of the appendix and remnant barium around the appendix. He was then pathologically diagnosed with a low-grade AMN based on the resected specimen, and the appendix filled with white globules was diagnosed as myxoglobulosis. When barium is not absorbed, it causes chronic inflammation. As barium was observed around the appendix, prolonged inflammation, and appendicitis may have contributed to the myxoglobulosis. The circumference of the appendix firmly adhered to the surrounding tissue with barium; hence, it was difficult to perform appendectomy. Barium that enters the anastomotic site causes stenosis of this part; therefore, excision of the ileocecal region in the intestinal part where barium is not present was selected instead of appendectomy. Colonoscopy performed 1 year after surgery and showed no evidence of anastomotic stricture. Conclusion This case suggested that barium peritonitis caused strong adhesions with the surrounding tissue; thus, careful manipulation was necessary to avoid perforating the appendix. Appendectomy and partial cecal resection were predicted to be difficult because of adhesion by barium. In addition, the ileocecal resection was selected because we had to choose an anastomotic site without barium. The perforated appendicitis caused stenosis of the appendix orifice, and barium surrounding the appendix caused persistent chronic inflammation. This was suggested to contribute to the myxoglobulosis.

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Section: Discussionmentioning

confidence: 99%

“…Barium leaks into the peritoneal cavity, causing strong adhesions [11]. Furthermore, stenosis of the anastomosed site occurs when barium is involved in the anastomosis [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Appendiceal mucinous neoplasm with myxoglobulosis occurring 3 years after perforated barium appendicitis: a case report

et al. 2019

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“…In the literature, the number of reported cases of myxoglobulosis is extremely rare. Recently, Aroukatos et al (10) reported that a case of myxoglobulosis of the appendix is associated with a ruptured diverticulum. Falah et al (11) have reported a case of appendiceal myxoglobulosis associated with peritonitis due to perforated peptic ulcer.…”

Section: Discussionmentioning

confidence: 99%

Myxoglobulosis in the appendix

Koçak

Zengin

Girgin³

et al. 2017

Turk J Surg

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Myxoglobulosis is a specific type of mucocele consisting of mucoid material. It is characterized by opaque, transparent globules that resemble "fish eggs" or "frogspawns". It is generally diagnosed incidentally during an appendectomy or an autopsy. In this paper, we aim to present the case of a 58-year-old male patient who was referred to our hospital because of abdominal pain and loss of appetite. The patient underwent an appendectomy. Opaque intraluminal globules were found in the appendectomy material. The globules resembled pearls and they were 2-3 mm in diameter. After histopathological examinations, the patient was diagnosed with myxoglobulosis accompanied with acute appendicitis. According to our research, this is the first case of myxoglobulosis in our country.

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“…Mucocele of the appendix, regardless of the underlying cause, is characterized by dilatation of the appendiceal lumen due to abnormal accumulation of mucus (8). Myxoglobulosis of the appendix, a subtype of appendiceal mucocele, is identified by the presence of mucinous, often calcified, pear-like globules in the lumen of the appendix (4). Myxoglobulosis occurs most frequently in the sixth or seventh decades of life with a female preponderance (7).…”

Section: Discussionmentioning

confidence: 99%

“…Whereas, the coexistence of multiple small intraluminal globoid bodies, accompanied by mucoid material resembling fish eggs, constitutes a special type of mucocele described as "myxoglobulosis" or "caviar ap-pendix". Myxoglobulosis is a rare finding (4,5) where the incidence of appendiceal mucocele with myxoglobulosis constituting only 0.35% to 0.8% of mucoceles (6,7).…”

Section: Introductionmentioning

confidence: 99%

Myxoglobulosis, a Rare Variant of Appendiceal Mucocele: Case Report and Review of the Literature

Falah

Maafi²,

Chatrnour³

et al. 2012

Thrita J Med Sci

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Appendiceal mucocele is a term referring to the abnormal accumulation of mucus into the lumen of appendix regardless of the underlying cause. Mucocele alone is not considered a rare finding in routine appendectomy. However, the coexistence of multiple small intraluminal globoid bodies as "myxoglobulosis" or "caviar appendix" is a rare finding. Case report: We report a 54 year old woman with complaint of abdominal pain who subequnetly had a surgery with the final diagnosis of peritonitis due to perforated peptic ulcer. During the operation, a jejunal mass and appendiceal dilation were observed incidentally. By histopathologic examination, a diagnosis of submucosal leiomyoma for jejunal mass, nonspecific ulceration for peptic specimen and cystadenoma with myxoglobulosis for appendix specimen was made. She had an uneventful postoperative course and after five months, she reported that she had not experienced any discomfort or pain. Conclusion: this report presents a rare case of appendiceal myxoglobulo sis secondary to mucinous cystadenoma, which was in cidentally found in patient with peritonitis due to peptic ulcer disease.

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Myxoglobulosis of the Appendix: A Case Associated with Ruptured Diverticulum

Cited by 6 publications

References 5 publications

Appendiceal mucinous neoplasm with myxoglobulosis occurring 3 years after perforated barium appendicitis: a case report

Appendiceal mucinous neoplasm with myxoglobulosis occurring 3 years after perforated barium appendicitis: a case report

Myxoglobulosis in the appendix

Myxoglobulosis, a Rare Variant of Appendiceal Mucocele: Case Report and Review of the Literature

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