Myxofibrosarcoma of the thyroid gland

Darouassi, Youssef; Attifi, Hicham; Zalagh, M.; Rharrassi, Issam; Benariba, Fouad

doi:10.1016/j.anorl.2013.09.004

Cited by 11 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cases have been reported in the heart [34], the aorta [6] the thyroid gland [7] and the brain [2]. To the best of our knowledge, our case is the first MFS primary of the kidney to be reported.…”

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Primary renal myxofibrosarcoma

Val-Bernal

García-González

Mayorga

et al. 2015

Pathology - Research and Practice

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 74%

“…Radical surgery combined with radiotherapy should be considered for all patients diagnosed with grade 2 or grade 3 MFS, and for those whose tumors show positive/close surgical resection margins [23]. Chemotherapy based on doxorubicin and ifosfamide has been used in tumor recurrence [7].…”

Section: Discussionmentioning

confidence: 99%

Primary renal myxofibrosarcoma

Val-Bernal

García-González

Mayorga

et al. 2015

Pathology - Research and Practice

View full text Add to dashboard Cite

“…The incidence of MFS in the head and neck region is quite rare [15]. The reported cases of MFS in the head and neck region were mostly in the soft tissues, such as the Schneiderian membrane of the maxillary sinus [16], lining of the sphenoid sinus [17], parotid gland [18], thyroid gland [19], and pharynx [20]. MFS occurring intra-osseously in the head and neck region is exceedingly rare.…”

Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma of the mandible: a case report and review of the literature

Liu

Zhang

et al. 2020

BMC Oral Health

View full text Add to dashboard Cite

Background: Myxofibrosarcoma (MFS) is a soft tissue sarcoma that commonly occurs in late adult life. It is mainly located in the subcutaneous soft tissues of extremities characterized by a high recurrence rate at the original site. MFS of the head and neck is rare, while it occurs in the maxilla and mandible is extremely rare. Case presentation: We report a case of MFS of the mandible in a 51-year-old female who presented with a painless gingival swelling and mobile, super-erupted right mandibular second and third molars. Panoramic x-ray and maxillofacial CT revealed an ill-defined radiolucent lesion surrounding the mandibular molars giving a teethfloating-in-air appearance. Histopathological examination showed scattered spindle and stellate cells with mild atypia distributed in the myxoid stroma. Only a few mitotic figures were identified and no area of tissue necrosis was found. The characteristic thin-walled and curvilinear vasculature were prominent. Immunohistochemistry analysis revealed the tumor cells being positive for vimentin and vascular CD31. CK, S-100, P63, HHF-35 stains were negative. The labeling index of Ki-67 was about 30%. Based on the histopathological and immunohistochemical examinations, the diagnosis of a low-grade MFS was established. This patient underwent a radical segmental excision with a 2-cm margin, supraomohyoid neck dissection and immediate reconstruction of the mandibular continuity defect with a fibular osteocutaneous free flap. This patient has been followed for 20 months to date and has remained disease free. Conclusions: This report describes a rare case of MFS of the mandible. Recognizing the histopathological features of MFS and applying the appropriate immunohistochemical examinations are crucial in establishing the correct diagnosis. Our case may provide diagnosis and treatment experiences of MFS occurs in the mandible.

show abstract

“…However, the 5-year local recurrence rate for MFS of the extremity is with 14.6% comparable to that of other soft tissue sarcoma (STS) subtypes [ 5 ]. To our knowledge, there are only 4 cases reported that involve the thyroid gland and that were diagnosed postoperatively (Table 1 ) [ 6 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Primary thyroid gland myxofibrosarcoma: a case report and review of the literature

et al. 2022

View full text Add to dashboard Cite

Background Myxofibrosarcoma is a common soft tissue sarcoma of the extremities, which occurs very rarely in the thyroid gland. Case presentation We report the case of a 61-year-old male who presented with a swelling of the left side of the neck and a newly emerged hoarseness. Ultrasound depicted a hypoechoic thyroid nodule with microcalcifications that was highly suspicious for malignancy. He underwent a left hemithyroidectomy. Histopathological examination and immunohistochemical studies revealed a myxofibrosarcoma of the thyroid gland. Conclusion Myxofibrosarcoma of the thyroid gland is extremely rare. The diagnosis is based on histopathological features. Radical surgery achieving tumor-free resection margins remains the only chance for cure. However, the role of radiotherapy and/or chemotherapy is still under debate. Due to their high tendency for locoregional recurrence, a close follow-up after surgery is mandatory.

show abstract

Myxofibrosarcoma of the thyroid gland

Cited by 11 publications

References 7 publications

Primary renal myxofibrosarcoma

Primary renal myxofibrosarcoma

Myxofibrosarcoma of the mandible: a case report and review of the literature

Primary thyroid gland myxofibrosarcoma: a case report and review of the literature

Contact Info

Product

Resources

About