Myxofibrosarcoma in the left atrium originally presented as a cardiac myxoma with chondroid differentiation

Abstract

Johansson, L., Kugelberg, J. & Thulin, L. Myxofibrosarcoma in the left atrium originally presented as a cardiac myxoma with chondroid differentiation. APMIS 97: 833-838. 1989.Malignant cardiac tumours located on heart valves are very rare. We report on a myxofibrosarcoma originally presented as a cardiac myxoma (CM), partly with chondroid differentiation, located on the posterior leaflet of the mitral valve. The tumor recurred twice, the first time disguised as a CM with only minor components of myxofibrosarcoma, and finally metastazised as a myxofibrosarcoma. Patient survival (40 months from first surgery) was surprisingly long and this may well reflect both the effectiveness of the combined radiation and cytostatic treatment and the histopathological features of the tumor.

Sarcoma of the pulmonary artery: report of four cases with electron microscopic and immunohistochemical examinations, and review of the literature

“…Immunohistochemical findings are outlined in Table 3. They arise at the base of the heart (mostly in the pulmonary artery but also in the atria or mitral valve) and are usually slowly aggressive (McConnell 1970;Johansson et al 1989) but eventually fatal because of their location. The reaction was distinct, although relatively weak, with cytokeratin AE1/AE3 (Fig.…”

Axillary artery tumor embolism secondary to mitral valve myxosarcoma in a dog

“…Lesions have been identified in the left ventricle, right atrium, right auricle, and on the tricuspid valve . To the authors’ knowledge, there is no report of myxosarcoma originating in the mitral valve in dogs, although it has been reported in people . To the authors’ knowledge, there are also no reports of tumor embolism to the axillary artery in a dog.…”

Primary intermediate-grade cardiac myxofibrosarcoma with osseous metaplasia: an extremely rare occurrence with a previously unreported feature

“…These cellular features, and the presence of necrosis, define its histologic grade, which has prognostic implications [1,5,9]. Only one case reported osteoid and bone formation in a "spindle cell sarcoma of the heart" [2] and another two cases reported with chondroid differentiation [10,11], but there are no previous intermediate-grade cases with osseous metaplasia in MFS. Immunohistochemistry profiling shows an intense reactivity for vimentin in all documented cases.…”