Myrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats

Yaman, Beril Kadıoğlu; Çevik, Özge; Yalman, Kübra; Ertaş, Büşra; Şen, Ali; Şener, Göksel

doi:10.1016/j.gene.2020.144616

Cited by 15 publications

(7 citation statements)

References 64 publications

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“…Kadıoğlu et al (2020) have been shown to reduce brain damage in ovariectomized rats by MC treatment. In addition, it was stated in this study that cognitive functions were impaired in parallel with the damage, but improved with MC treatment [31]. This positive effect of MC treatment on memory was supported by Aykaç et al (2019) and they have reported the decrease in cognitive functions with scopolamine was reversed with MC [24].…”

Section: Discussionsupporting

confidence: 78%

“…In an in vitro analysis Tumen et al (2012) have reported that Myrtus communis extract inhibited AChE activity [23]. More recently, Kadıoğlu et al (2020) have demonstrated that increased AChE activity in the brain was suppressed by MC in ovariectomized rats [31].…”

Section: Discussionmentioning

confidence: 98%

“…Increased AChE activity and oxidative stress in the hippocampus may cause this deterioration of the recognition memory. On the other hand, MC therapy has been shown to improve deteriorated recognition memory in ovariectomized diabetic rats [31] and scopolamine-induced Alzheimer's model [24]. Also, Romani et al (1999) reported that MC contained phenolic compounds such as catechin and myricetin-derived compounds as major constituents [20].…”

Section: Discussionmentioning

confidence: 99%

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Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Özbeyli¹,

YARIMBAŞ²,

Ertaş³

et al. 2020

JRP

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Obesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus communis extract (MC) has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus communis on oxidative brain damage caused by a high-fat diet (HFD), using behavioral and biochemical parameters. Twenty-four Wistar albino rats (200-250 g) were divided into three groups. The control group (C) received a standard diet, while HFD groups were received HFD for 16 weeks. MC (100 mg/kg, oral) was given to the HFD + MC group for the last 4 weeks. At the end of the study, the novel object recognition test (NORT) was performed and the hippocampus and blood samples were collected. Acetylcholinesterase (AChE) and Na + /K +-ATPase activities, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and reduced glutathione (GSH) levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na⁺ /K⁺-ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutritioninduced obesity.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Özbeyli¹,

YARIMBAŞ²,

Ertaş³

et al. 2020

JRP

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“…An hour later, the rat was observed and video-taped for 3 minutes in the box containing the old and a new object (A + B) (test phase). During all experiments, the box and objects were cleaned with 70% alcohol solution before the test of the next animal [52].…”

Section: New Object Recognition Testmentioning

confidence: 99%

Nicorandil preserves blood-brain barrier and improves memory impairment in hypertensive rats

Yakut¹,

Ertaş²,

Koyuncuoğlu³

et al. 2019

Sanat

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In renovascular hypertension (RVH), oxidative stress and inflammation due to high blood pressure and elevated levels of angiotensin 2 are mainly responsible of cerebrovascular complications and impaired cognitive functions. Since the nicorandil has been shown to exert neuroprotective, anti-inflammatory and antioxidant effects, we investigated the effect of nicorandil against vascular dementia and blood brain barrier damage in a rat model of angiotensin-dependent hypertension. Wistar albino rats, were divided as sham-operated control, renovascular hypertension (RVH) and Nicorandil-treated RVH groups. Silver clip was implanted onto the left renal artery. Using the tail-cuff method, blood pressure of rats was measured before the surgery and at the end of the post-surgical 3 rd and 12 th weeks. Nicorandil (4mg/kg, orally) or vehicle was administered for 9 weeks. Twelve weeks after RVH surgery, a new object recognition test was performed. Following the determination of blood brain barrier integrity, serum samples were taken for the evaluation of proinflammatory cytokines tumor necrosis alpha (TNF-α) and interleukin-1 beta (IL-1β). Levels of sodium-potassium adenosine triphosphatase (Na + /K +-ATPase), as a marker of endothelial damage, were evaluated in the hippocampal tissues. RVH resulted in significant increases in TNF-α and IL-1β levels and decreases in Na + /K +-ATPase levels, along with impairment in blood brain barrier integrity and memory performance. In the nicorandil treatment group, these indices were reversed back to control levels. The present data demonstrated that nicorandil attenuates RVH-induced memory impairment and blood brain barrier damage in rats with RVH.

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“…Cholinergic transmission is known to play a crucial role in cognitive functions containing learning and memory. [3][4][5][6] In line with this perspective, changes in acetylcholine (ACh) levels are involved in the regulation of learning and memory or depression-like behaviors, it is known that brain ACh levels are elevated in depressed patients and remain at this level as long as depression persists, 7 and acetylcholinesterase (AChE) activity is the main regulator of ACh levels. 8 However, there are inconsistent results regarding the effect of AChE activity on these functions in cognitive dysfunctions.…”

Section: Introductionmentioning

confidence: 97%

The effects of donepezil on anxiety- and depression-like behaviors in diabetic rats and the role of nitric oxide modulators

ÖZ>¹,

Atalık²,

Aslanlar³

2023

KMJ

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Aims: The aim of the present study was to evaluate the effect of an acetylcholinesterase inhibitor donepezil on the diabetes-induced anxiety and depression and the role of nitric oxide in these effects. Methods: Thirty male Wistar rats were randomly divided into 2 groups at first; the control group (n=6) and the diabetic group (n=24). The diabetic group divided into four groups, a single dose of streptozotocin was used to induce experimental type 1 diabetes. After 30 days, one group was separated as diabetic control, while the other three received 4 mg/kg p.o. donepezil for 20 days. One of the DON groups was administered 20 mg/kg i.p., L-NAME for 20 days, while the other group was administered 40 mg/kg i.p., L-arginine for 20 days. Results: Anxiety-like behaviors were assessed using the open field test (OFT), and depression-like behaviors were estimated using the forced swim test (FST). In the OFT, all diabetic rats spent less time in the center and engaged in less exploratory behavior than the control group. The number of lines crossed where locomotor activity was assessed did not differ significantly between groups. In the FST, duration of immobility increased significantly in diabetic groups compared to the control. Donepezil administration did not affect either depression or anxiety responses. Moreover, donepezil plus L-arginine increased diabetes-induced depression significantly. Conclusion: These findings may suggest that cholinergic and nitrergic systems may interact on depression-like behaviors in diabetic rats.

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Myrtus communis subsp. communis improved cognitive functions in ovariectomized diabetic rats

Cited by 15 publications

References 64 publications

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

Nicorandil preserves blood-brain barrier and improves memory impairment in hypertensive rats

The effects of donepezil on anxiety- and depression-like behaviors in diabetic rats and the role of nitric oxide modulators

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