2007
DOI: 10.1016/j.biochi.2007.07.001
|View full text |Cite
|
Sign up to set email alerts
|

Myristic acid increases the activity of dihydroceramide Δ4-desaturase 1 through its N-terminal myristoylation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
45
0
6

Year Published

2008
2008
2015
2015

Publication Types

Select...
7
1

Relationship

3
5

Authors

Journals

citations
Cited by 47 publications
(55 citation statements)
references
References 34 publications
4
45
0
6
Order By: Relevance
“…The fatty acyl-CoA composition of RAW264.7 and MCF7 cells displayed a diverse set of fatty acyl-CoA species, including those that may participate in the modification of proteins, such as C14:0-CoA (17), and those that connect lipid biosynthesis with lipid signal transduction pathways, such as C20:4-CoA (18). The most obvious difference in the fatty acyl-CoA compositions of RAW264.7 versus MCF7 cells is the proportion of the total fatty acyl-CoAs that have C20 and longer chain lengths, which amounts to more than half of the total in MCF7 cells but is near the LOQ in RAW264.7 cells.…”
Section: Discussionmentioning
confidence: 99%
“…The fatty acyl-CoA composition of RAW264.7 and MCF7 cells displayed a diverse set of fatty acyl-CoA species, including those that may participate in the modification of proteins, such as C14:0-CoA (17), and those that connect lipid biosynthesis with lipid signal transduction pathways, such as C20:4-CoA (18). The most obvious difference in the fatty acyl-CoA compositions of RAW264.7 versus MCF7 cells is the proportion of the total fatty acyl-CoAs that have C20 and longer chain lengths, which amounts to more than half of the total in MCF7 cells but is near the LOQ in RAW264.7 cells.…”
Section: Discussionmentioning
confidence: 99%
“…Chez l'homme, un régime assurant un apport modéré en acide myristique (1,2 % de l'énergie totale), comparé à un régime assurant un apport plus faible (0,6 %), augmente également les taux de DHA et d'EPA dans les phospholipides plasmatiques et le taux de DHA dans les esters de cholestérol plasmatiques [39]. Le mécanisme moléculaire à l'origine de l'activation par le C14:0 de la Δ6-désaturase dans le modèle cellulaire n'est pas identifié, mais l'hypothèse d'une myristoylation de l'enzyme, qui possède une Glycine amino-terminale, a été récemment écartée [40]. Une autre protéine du complexe Δ6-désaturant, la NADH-cytochrome b5 réductase, est en revanche myristoylée et son niveau de myristoylation pourrait donc être un paramètre de régulation [41].…”
Section: Acide Myristique Et Régulation De La Biodisponibilité Des Acunclassified
“…En plus de leur rôle structural dans la membrane plasmique, ils interviennent dans des processus cellulaires comme l'apoptose, la réponse au stress ou la croissance cellulaire. Récem-ment, une nouvelle protéine myristoylée intervenant dans le métabolisme de ces lipides a été découverte [40]. Il s'agit de la dihydrocéramide Δ4-désaturase (DES) qui catalyse la dernière étape de la biosynthèse de novo du céramide (le précurseur de tous les sphingolipides) en introduisant une double liaison en position 4 sur le dihydrocéramide.…”
Section: Acide Myristique Et Régulation De La Biodisponibilité Des Acunclassified
See 1 more Smart Citation
“…Some studies show that, for example, myristic acid plays a key role through its ability to acylate proteins, a (Casey, 1995;. Myristic acid also has a function in the biosynthesis of EPA and DHA and of sphyngolipids (Beauchamp et al, 2007). C20:0, C22:0, C24:0 have a role in nervous structure (myelinisation) (Bourre et al, 1976a and b).…”
Section: Categories Structure and Functionmentioning
confidence: 99%