Myricetin: a potential plant-derived anticancer bioactive compound—an updated overview

Flavonoids as promising molecules in the cancer therapy: An insight

“… Han et al (2018) Myricetin Inhibits metastasis via inhibition of cell migration as seen in prostate cancer. Ye et al (2018) Kumar et al (2023) Galangin Decreased cellular proliferation by initiation of apoptosis via PI3K/akt/mTOR signalling pathway in human kidney (A498) cancer cell line. ( Zhu et al ) Flavonones Hesperetin Initiated apoptosis in H522 lung cancer cells Elango et al (2018) Naringenin Decreased cancer metastasis via voltage gated sodium channels and initiated both early and late apoptosis in prostate cancer Gumushan Aktas and Akgun (2018) Flavonols Taxifolin Decreased carcinogenesis through mTOR/PTEN axis and CYP1B1 mediated cancer Haque et al (2018) Flavans Epigallocatecatechingallate (EGCG) Increased chemoprevention and apoptosis through Abl/Bcrmediated p38-JAK2/STAT3/Akt and MAPK/JNK pathways in chronic myeloid leukemia and Glioblastoma cancer cells respectively Grube et al (2018) EGCG, catechin Decreased cancer growth through programmed cell death Xiao et al (2019) Anthocyanidins Cyanidin Decreased angiogenesis in MCF-7 cells through STAT3/VEGF signalling pathway Ma and Ning (2019) Delphinidin Increased initiation of apoptosis and induction of autophagy in HER2 positive MDA-MB-453 cancer cells Chen et al (2018) Isoflavonoids Genistein Increased apoptosis and decreased cellular proliferation in human laryngeal Mcl-1 and EP3 expressing melanoma cancer cells respectively …”

A novel drug–drug cocrystal of tegafur and myricetin: optimized properties of dissolution and tabletability

“…Myricetin (MYR, Scheme 1) is a widespread, active ingredient of traditional Chinese medicine with antioxidant, antibacterial, antiviral, antihypertensive, hypoglycemic activities and so on. 18–21 The MYR also exhibits a good anti-tumor effect which can inhibit the proliferation of many cancer cells including liver cancer, colon cancer and breast cancer by blocking the cell cycle, inducing mitochondrial mediated apoptosis, inhibiting tumor angiogenesis and so on. 22–24 In particular, MYR can prevent 5FU induced cardiotoxicity, and was found to enhance the chemosensitivity of 5FU on esophageal carcinoma in vitro and in vivo .…”