Flavonoids as promising molecules in the cancer therapy: An insight

Mir, Suhail Ahmad; Dar, Ashraf; Hamid, Laraibah; Nisar, Nasir; Malik, Jonaid Ahmad; Ali, Tabasum; Bader, Ghulam Nabi

doi:10.1016/j.crphar.2023.100167

Cited by 9 publications

(1 citation statement)

References 180 publications

(168 reference statements)

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“…Inflammatory processes play a multifaceted role in tumor development and progression [1][2][3][4][5][6][7]. While the immune system's inflammatory response is typically a defense mechanism against infections and tissue damage, chronic or persistent inflammation can contribute to the initiation, growth, and spread of certain types of tumors.…”

Section: Introductionmentioning

confidence: 99%

Nerve Growth Factor and the Role of Inflammation in Tumor Development

Ferraguti,

Terracina,

Tarani

et al. 2024

CIMB

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Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.

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Section: Introductionmentioning

confidence: 99%

Nerve Growth Factor and the Role of Inflammation in Tumor Development

Ferraguti,

Terracina,

Tarani

et al. 2024

CIMB

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A Tumor Targeting Strategy of Phytoflavonoid Biochanin A for Efficient Fluorescence‐Guided Chemotherapy

Park,

Jo,

Hyun

2024

Small Science

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Cancer chemotherapy using natural phytochemicals, especially including isoflavone biochanin A (BCA), has attracted considerable attention because of the potent antitumor therapeutic effect and excellent biosafety. However, the preclinical application of BCA is still generally limited by its poor water solubility and low biological availability. To overcome these important limitations, a tumor targetable hemicyanine‐based near‐infrared (NIR) theranostic agent is rationally designed and prepared to improve the water solubility, tumor targetability, and antitumor activity of BCA. A key point to enhance the tumor targeting efficiency of BCA is the combination of a tumor‐targeted water‐soluble zwitterionic NIR fluorophore (ZW800‐Cl) and BCA to create the hemicyanine structure, named BCA‐ZW. Owing to the long‐wavelength emission (>750 nm) and large Stokes shift (72 nm) of BCA‐ZW, the in vivo performance of BCA‐ZW is effectively monitored. The molecularly engineered BCA‐ZW not only exhibits high targeting ability to HT‐29 xenograft tumors but also induces high levels of reactive oxygen species (ROS) generation in the tumor tissues. Therefore, the fluorescence‐guided chemotherapy by BCA‐ZW to the tumor‐bearing mouse model achieves the enhanced antitumor effect of BCA. This work provides a simple but effective strategy to design NIR fluorescent phytoflavonoids as potential therapeutic agents for further biomedical applications.

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