Myrianthus arboreus P. Beauv improves insulin sensitivity in high fat diet-induced obese mice by reducing inflammatory pathways activation

The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice

“…HFD consumption increased body weight gain over 31 days compared to those mice that were fed a control diet ( Figure 5 A), according to previous studies [ 28 , 29 ]. However, the daily administration of LME to HFD-fed mice significantly diminished weight gain from day 6 ( Figure 5 A); of note, no satiating effect was shown since similar food-intake values were observed in all HFD-fed groups throughout the experiment ( Figure 5 B,C).…”

“…Unlike leptin, adiponectin is generally related to anti-inflammatory and antioxidant properties in obesity through the downregulation of the expression and the release of several proinflammatory immune mediators [ 37 ], especially TNF-α. As expected, the gene expression of both adipokines, Lep and Adipoq, were altered in the fat tissue of obese mice, as also described in other diet-induced obesity models [ 29 , 39 ], along with a reduced expression of Lepr (Leptin Receptor) ( Figure 8 B). Interestingly, the expression levels of these markers were ameliorated after LME administration to HFD-fed mice, which correlated with the improvement of insulin resistance and the associated hyperglycemia.…”