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. Design of the study, acquisition of data, critical revising and final approval of the version to be published. ABSTRACT PURPOSE:This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS:The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. RESULTS: CONCLUSION:These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.

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Highlights Modified malt was successfully used in Capsicum oleoresin microencapsulation. High antioxidant activities by ORAC and FRAP were observed for all microparticles. Diet containing Capsicum oleoresin microparticles can promote weight gain control. Liver damage caused by obesity was prevented by high doses of Capsicum's oleoresin.

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