Myostatin expression and possible functions in animal muscle growth

Kocamiş, Hakan; Killefer, J.

doi:10.1016/s0739-7240(02)00178-9

Cited by 41 publications

(26 citation statements)

References 30 publications

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“…In-vitro studies demonstrate that recombinant myostatin inhibits the proliferation of C2C12 myoblasts and bovine myoblasts derived from 160-day-old fetuses (Thomas et al, 2000). Also, the inhibitory effect of myostatin was shown to be reversible, as myoblasts maintained their ability to proliferate when myostatin was removed (Kocamis & Killefer, 2002). Furthermore, satellite cell proliferation and differentiation are inhibited by myostatin, which maintains them in their quiescent state and down regulates the expression of MyoD family members (Halevy et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Thermal Manipulation Mid-term Broiler Chicken Embryogenesis: Effect on Muscle Growth Factors and Muscle Marker Genes

Al‐Zghoul

Al-Natour

Dalab

et al. 2016

Rev. Bras. Cienc. Avic.

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Thermal manipulation (TM) during broiler chicken embryogenesis has been shown to promote muscle development and growth. However, the molecular bases of promoting broiler muscle development and growth are not fully understood. The aim of this study was to investigate the molecular bases of muscle growth and development in broiler chickens subjected to TM. This included the investigating of the changes in mRNA expression levels of muscle marker genes, namely MyoD, myogenin, paired box transcription factor (Pax7) and proliferating cell nuclear antigen (PCNA), and muscle growth factors namely insulin-like growth factor 1 (IGF-1), myostatin and growth hormone (GH) during embryogenesis and on posthatch days 10 and 28. Fertile Cobb eggs (n=1500) were divided into four groups. Eggs in the first group (control) were incubated at 37.8°C and 56% RH, whereas, eggs in the second group (TM 1 ) , third group (TM 2 ) , and fourth group (TM 3 ) were subjected to 39 ºC and 65% RH daily during embryonic days (ED) 12-18 for 9, 12, and 18 hours, respectively. Body weight (BW) during embryogenesis and posthatch days (1, 3, 5, 7, 14, 21, 28 and 35) was recorded. mRNA expression levels of muscle marker genes and muscle growth factor genes during ED 12, 14, 16 and 18 and on posthatch days 10 and 28 were analyzed using real-time RT-PCR. TM upregulated the mRNA expressions of muscle marker and growth factors genes. This upregulation was accompanied by improvement of body weight near and at market age.

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Section: Discussionmentioning

confidence: 99%

Thermal Manipulation Mid-term Broiler Chicken Embryogenesis: Effect on Muscle Growth Factors and Muscle Marker Genes

Al‐Zghoul

Al-Natour

Dalab

et al. 2016

Rev. Bras. Cienc. Avic.

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“…Myostatin inhibits cell proliferation Myostatin (Mst), also known as growth and differentiation factor 8 (GDF-8), is a secreted negative regulator of muscle Signalling and pathways in molecular determination of skeletal muscle phenotype mass that belongs to the transforming growth factor (TGF)-b superfamily (Kocamis and Killefer, 2002). Its biological significance is demonstrated in several breeds of double-muscling cattle (e.g.…”

Section: Fibre Number: Mediators Of Muscle Hyperplasiamentioning

confidence: 99%

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

Chang

2007

Animal

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The molecular basis and control of the biochemical and biophysical properties of skeletal muscle, regarded as muscle phenotype, are examined in terms of fibre number, fibre size and fibre types. A host of external factors or stimuli, such as ligand binding and contractile activity, are transduced in muscle into signalling pathways that lead to protein modifications and changes in gene expression which ultimately result in the establishment of the specified phenotype. In skeletal muscle, the key signalling cascades include the Ras-extracellular signal regulated kinase-mitogen activated protein kinase (Erk-MAPK), the phosphatidylinositol 3 0 -kinase (PI3K)-Akt1, p38 MAPK, and calcineurin pathways. The molecular effects of external factors on these pathways revealed complex interactions and functional overlap. A major challenge in the manipulation of muscle of farm animals lies in the identification of regulatory and target genes that could effect defined and desirable changes in muscle quality and quantity. To this end, recent advances in functional genomics that involve the use of micro-array technology and proteomics are increasingly breaking new ground in furthering our understanding of the molecular determinants of muscle phenotype.

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“…However, it is questionable whether this relatively small reduction, of less than one third that found in humans (Walker et al, 2004), could on its own account for the degree of exercise-induced hypertrophy observed. The doublemuscled phenotype is only observed in three of the six breeds of cattle that possess a functional mutation in the myostatin protein, which suggests that dysfunction of one major gene may not entirely account for the increase in muscle mass (reviewed by Kocamis and Killefer, 2002). Similarly, inhibition of myostatin in transgenic zebrafish only resulted in a 20% increase in muscle fibre number (Xu et al, 2003).…”

Section: Myostatin -A Negative Regulator Of Muscle Growth Inmentioning

confidence: 99%

The role of myostatin and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow troutOncorhynchus mykissWalbaum

Martin

Johnston

2005

Journal of Experimental Biology

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SUMMARY Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s-1 for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout.

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Myostatin expression and possible functions in animal muscle growth

Cited by 41 publications

References 30 publications

Thermal Manipulation Mid-term Broiler Chicken Embryogenesis: Effect on Muscle Growth Factors and Muscle Marker Genes

Thermal Manipulation Mid-term Broiler Chicken Embryogenesis: Effect on Muscle Growth Factors and Muscle Marker Genes

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

The role of myostatin and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow troutOncorhynchus mykissWalbaum

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