Myositis ossificans circumscripta of the knee improved by alendronate

Hamida, Kaouther Saadallaoui Ben; Hajri, R.; Kedadi, H.; Bouhaouala, H.; Salah, Morshed Ali; Mestiri, A.; Zakraoui, L.; Doughi, M.H.

doi:10.1016/s1297-319x(03)00096-4

Cited by 28 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Osteoblasts and osteoid deposits are visible in the intermediate zone. The outermost zone is a shell of mature bone [10]. In the present case, macroscopic zonation was not seen, probably because the ossification oc- curred over 16 years.…”

Section: Discussioncontrasting

confidence: 46%

“…Plain radiographs reveal either ossifications arranged in a ring around a central lucent area or a more or less homogenous calcified mass [10]. CT scan shows that the underlying cortical bone is intact and that there is a space between the mass and the neighboring bone [10].…”

Section: Discussionmentioning

confidence: 99%

“…CT scan shows that the underlying cortical bone is intact and that there is a space between the mass and the neighboring bone [10]. The MRI appearances of HO are variable and depend on the maturity of the lesion.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Heterotopic Ossification of the Distal Portion of Biceps Femoris

Yabe

Hatori

Kumagai

et al. 2006

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Heterotopic ossification is the formation of mature lamellar bone in soft tissue. We report a very unusual case of heterotopic ossification arising in the distal portion of the biceps femoris muscle. A 29-year-old woman presented with knee pain after playing golf. She had had no apparent history of trauma. Radiography of the knee showed a calcified mass adjacent to the lateral side of her knee joint. The radiological diagnosis was calcification of the lateral collateral ligament. The pain soon disappeared without treatment. At the age of 45 years, she complained of a growing mass in her left knee that was occasionally painful. Computed tomography and magnetic resonance imaging demonstrated a well matured ossified mass in the lateral side of her left knee. Radiologically and macroscopically, it was found to be in continuity with the distal part of biceps femoris. The mass was excised en bloc. Microscopically, the lesion was mainly composed of well-matured lamellar bone with bone marrow and islands of cartilage showing enchondral ossification. No apparent zoning was found. Cellular atypia was not observed. Extraskeletal osteosarcoma was ruled out. The mass was diagnosed as a heterotopic ossification arising from the distal part of biceps femoris.

show abstract

Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heterotopic Ossification of the Distal Portion of Biceps Femoris

Yabe

Hatori

Kumagai

et al. 2006

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

show abstract

“…In the majority of cases, it is asymptomatic and can be managed with non-operative treatments with spontaneous resolution monitored by imaging exams. Biphosphonate therapy with oral medication, which has potent anti-osteoclastic effects, can be prescribed in the acute phase with favourable outcomes [36]. If MO progress to permanently limit range of motion and function with pain or when the lesion is vulnerable to a repeated trauma causing disability, surgical intervention to remove persistent calcium deposits can be pointed out.…”

Section: Myositis Ossificansmentioning

confidence: 99%

Surgical treatment for muscle injuries

Ramos

Carvalho

Abdalla

et al. 2015

Curr Rev Musculoskelet Med

View full text Add to dashboard Cite

Muscle injury causes functional impairment. The healing process takes time and fibrotic tissue can result. Recurrence and delayed recovery remain as unsolved problems. Surgical intervention can be a feasible alternative to avoid early and late complications associated with complete muscle tear in attempt to improve functional results. This article hopes to provide an update about surgical treatments for muscle tears in different scenarios.

show abstract

“…[39][40][41][42][43] Only single case reports have been published for the treatment with the more potent new generation of amino-bisphosphonates. 44 Herein we report our observational experience using the aminobisphosphonate Pamidronate in five consecutive patients with established HO. Thereafter, a therapeutic algorithm is suggested.…”

Section: Introductionmentioning

confidence: 99%

Amino-bisphosphonates in heterotopic ossification: first experience in five consecutive cases

et al. 2005

View full text Add to dashboard Cite

Study design: Retrospective, observational study in five consecutive cases. Objectives: The management of heterotopic ossification (HO), a frequent complication after spinal cord injury (SCI) and after orthopaedic surgery, is a therapeutic challenge with high recurrence rates of over 50%. Conflicting data were reported for Etidronate. The use of the more potent new generation of amino-bisphosphonates has been put forward in different inflammatory, dysmorphogenic bone disease. In order to try and halt the underlying dysfunctional bone metabolism we have studied the action of pamidronate in five consecutive high-risk patients with established HO of different etiology undergoing surgical removal. Setting: University Hospital of Basel, Switzerland, Division of Endocrinology, Diabetology and Clinical Nutrition and the Department of Orthopedic Surgery. Methods: In all five patients, ranging from 47 to 68 years of age, we used continuous pamidronate infusions perioperatively at a dosage of 120 mg in the first 12 h and subsequent reduction to 75-60-30-15 mg/12 h over a period of 10-14 days. Results: None of these patients showed clinical, radiographical and laboratory signs of HO recurrence or new forming HO in the follow-up 5-54 month after surgery. Potential side effects of high-dose bisphosphonate therapy such as osteoporosis and osteomalacia were not reported in any case. Conclusion: We postulate that pamidronate might have pronounced beneficial effects in highrisk patients with established HO undergoing excision surgery. Since the therapeutic window of amino-bisphosphonates has not yet been defined and the minimal necessary doses for preventing new HO are unknown, further studies are encouraged to confirm our findings and to identify the necessary dosage and duration of treatment and to pinpoint, which patients will benefit most from this treatment.Spinal Cord (2005) 43, 604-610.

show abstract

Myositis ossificans circumscripta of the knee improved by alendronate

Cited by 28 publications

References 0 publications

Heterotopic Ossification of the Distal Portion of Biceps Femoris

Heterotopic Ossification of the Distal Portion of Biceps Femoris

Surgical treatment for muscle injuries

Amino-bisphosphonates in heterotopic ossification: first experience in five consecutive cases

Contact Info

Product

Resources

About