Myositis ossificans circumscripta of the supra-orbital region: A case report

Ajike, SO; Mohammed, A.; Adebayo, Ezekiel Taiwo; Ononiwu, CN; Omisakin, OO

doi:10.4103/1596-3519.55694

Cited by 3 publications

(2 citation statements)

References 12 publications

(28 reference statements)

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“…Heterotopic ossification occurs as a complication after hip or knee surgery, and trauma, severe burns, or genetic disorders 4,5. Craniomaxillofacial HO is uncommon and, in several reported cases, is primarily related to previous surgeries involving the masticatory muscles 6–8…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Removal of Supraperiosteal Heterotopic Ossification of the Forehead

Seo

Lee

2022

Journal of Craniofacial Surgery

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Heterotopic ossification (HO) refers to the mature lamellar bone structure that develops locally in soft-tissue sites. Heterotopic ossification is known to occur mainly in the traumatic area or the muscle and joint capsule after surgery such as total hip arthroplasty or total knee arthroplasty. The pathophysiological cause of HO is not precisely known, but it seems to be related to some genetic predisposition. Craniomaxillofacial HO is rare and, in several reported cases, is primarily related to previous surgeries involving the masticatory muscles. The authors report on a patient who underwent endoscopic removal of a bone mass in the forehead. He completely denied any history of forehead trauma or surgery. There were no scars, trauma, or surgical marks found on the patient’s forehead. Preoperative magnetic resonance imaging showed that the mass was granuloma, but histological examination after surgical removal confirmed it as HO.

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Section: Discussionmentioning

confidence: 99%

Endoscopic Removal of Supraperiosteal Heterotopic Ossification of the Forehead

Seo

Lee

2022

Journal of Craniofacial Surgery

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“…In older patients, the diagnostic zonal bone deposition is often partial or absent so that 1 must rule out an extraskeletal osteosarcoma. There are 3 reports in the ophthalmic literature [30][31][32] alleging to be examples of myositis ossificans. They do not, however, histopathologically fulfill the foregoing diagnostic criteria but rather represent a congeries of nondescript, probably benign or reactive fibroosseous lesions.…”

Section: Differential Diagnosis Of Primary Conjunctival Lesionsmentioning

confidence: 99%

Epibulbar Proliferative Fasciitis, a Variant of Nodular Fasciitis: A Differential Diagnosis of Conditions With Focal or Diffuse Myxoid Stromas

Barrantes

Mihm

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe the clinical and pathologic features of a case of epibulbar proliferative fasciitis and to compare it with other focal or diffuse myxoid lesions. Methods: A clinical, histopathologic, and immunohistochemical analysis was performed. The clinical history, photographic documentation, history, and referred slides were reanalyzed. Additional immunohistochemical stains were performed at our institution. Results: A 68-year-old woman developed over a week a brightly vascularized and focally hemorrhagic placoid lesion on the temporal side of the OS. She had had earlier augmentation breast surgery that had been mistakenly initially reported to us to be for breast carcinoma. Hematoxylin- and eosin-stained reactions revealed microscopically a spindle cell lesion with an intact nonkeratinizing epithelium and a background myxoid stroma with prominent capillaries and a light dispersion of small T-cell lymphocytes. Most striking among the spindle cells were some widely separated large atypical cells. The atypical cells were cytokeratin positive, but an expansive panel of immunohistochemical stains for breast carcinoma was negative. The lesion was diagnosed as proliferative fasciitis and has not recurred after 1-year follow up. Conclusion: A rapidly evolving conjunctival lesion is unlikely to be a primary or metastatic carcinoma. In the current case, the large ganglioform or rhabdomyoblast-like cells displayed diffuse cytokeratin positivity, still consistent with a mesenchymal or connective tissue cell lineage. Cytokeratin expression has been a finding previously reported in connective tissue tumors and in lymphoma cells. While the current lesion clinically resembles a conventional nodular fasciitis, the presence of the large atypical cells can lead to the misdiagnosis of a sarcoma, which typically displays a much higher Ki-67 proliferation index in comparison with nodular/proliferative fasciitis.

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Heterotopic ossification in systemic sclerosis

Botzoris

Argyropoulou

et al. 2009

Scandinavian Journal of Rheumatology

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Although myopathy or myositis may occur in systemic sclerosis (SSc) as well as soft tissue calcification, ossification is not a feature of the disease. Here we present an unusual case of extended calcification and, to a lesser degree, ossification of the right gluteal region, lateral thigh, and knee, with associated myopathy and functional impairment. Heterotopic ossification (HO), or myositis ossificans, has not been reported so far in scleroderma patients, making this case, in our opinion, unique and interesting. However, differential diagnosis from other causes of extraskeletal ossification, such as tumours or tumour-like conditions, is required.

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Myositis ossificans circumscripta of the supra-orbital region: A case report

Cited by 3 publications

References 12 publications

Endoscopic Removal of Supraperiosteal Heterotopic Ossification of the Forehead

Endoscopic Removal of Supraperiosteal Heterotopic Ossification of the Forehead

Epibulbar Proliferative Fasciitis, a Variant of Nodular Fasciitis: A Differential Diagnosis of Conditions With Focal or Diffuse Myxoid Stromas

Heterotopic ossification in systemic sclerosis

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