Heterotopic ossification in systemic sclerosis

Botzoris, V. G.; Argyropoulou, Maria I.; Pv, Voulgari; Zikou, Anastasia; Drosos, Alexandros A.

doi:10.1080/03009740902776919

Cited by 15 publications

(6 citation statements)

References 18 publications

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“…The head and neck is also a well‐described location for traumatic HO . HO may occur in the skin, particularly in autoimmune disorders such as dermatomyositis and systemic sclerosis . The digits are also a well‐described site for HO, in which case the term “fibro‐osseous pseudotumor of the digits” is also used .…”

Section: Clinical Features Of Heterotopic Ossificationmentioning

confidence: 99%

“…In a simplistic conceptualization, inflammation is a key “niche factor” for the development of HO and a commonality across many of the conditions that predispose to HO formation. HO is known to occur in autoimmune diseases such as limited cutaneous systemic sclerosis, dermatomyositis, and inflammatory arthritis . Autoimmune diseases affecting the nervous system have also been reported as predisposing factors to HO, including anti‐NMDA receptor encephalitis and Guillain‐Barre syndrome .…”

Section: Basic Biologic Features Of Heterotopic Ossificationmentioning

confidence: 99%

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Heterotopic Ossification: A Comprehensive Review

et al. 2019

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Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite “niche” factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Section: Clinical Features Of Heterotopic Ossificationmentioning

confidence: 99%

Section: Basic Biologic Features Of Heterotopic Ossificationmentioning

confidence: 99%

Heterotopic Ossification: A Comprehensive Review

et al. 2019

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“…Aberrant ossification has also been observed in conditions treated with prostheses such as breast augmentation, [33] hip arthroplasty, [34] hyoid suspension, [35] temporomandibular joint reconstruction, [36] and tibiofibular syndesmosis, [37] and even in autoimmune diseases such as dermatomyositis, [38] systemic sclerosis, [39] and giant cell arteritis [40] . Foreign body giant cells have been observed in these autoimmune diseases, although not simultaneously with ossification [41–43] …”

Section: Discussionmentioning

confidence: 99%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

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Rationale:Pilomatricoma is a benign skin appendageal tumor derived from hair follicle matrix cells that commonly affects the head, neck, and upper extremities of the pediatric population. Since the original tumor description, diverse variants have been reported in the literature. Pilomatricoma with florid osseous metaplasia is described as an ossifying pilomatricoma and is recognized as a distinct variant of this benign tumor. However, the pathogenesis of this variant remains unclear. In this study, we present an uncommon case of ossifying pilomatricoma and address the pathogenesis of metaplastic ossification through a comprehensive literature review.Patient concerns:A 14-year-old boy presented with an asymptomatic protuberant mass in the preauricular region.Diagnosis:Based on its clinicopathological features, we diagnosed the lesion as an ossifying pilomatricoma.Interventions and outcomes:The lesion was surgically removed under local anesthesia. The postoperative course was uneventful during the 6-month postoperative follow-up.Lessons:We suggest that metaplastic ossification in ossifying pilomatricoma represents another feature of foreign body reaction to keratinous materials containing shadow cells in old lesions and a walling-off phenomenon to prevent exposure of surrounding tissues to keratinous materials.

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“…However, we could verify the extreme rarity of ossification in progressive systemic sclerosis in general, as only 5 cases associated with ossification involving soft tissue and skin have been published. 66,[138][139][140][141][142] In addition, patients with systemic sclerosis sometimes manifest calcareous lesions in the distal extremities, which have been analogized to a peripheral form of tumoral calcinosis. 143 Our case 2 of the 58-year-old man was considered idiopathic, despite the finding of those distinctive tendinous fibrous nodules, similar to what one sees in the lungs of patients with Ehlers-Danlos syndrome (EDS).…”

Section: Authors' Commentmentioning

confidence: 99%

Selected Case From the Arkadi M. Rywlin International Pathology Slide Series

Bisceglia¹,

Chiaramonte

Panniello

et al. 2015

Advances in Anatomic Pathology

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Two cases of diffuse dendriform pulmonary ossification (DPO) are presented, one of the secondary type and the other of the idiopathic type. Case 1 was an adult female patient who underwent thoracic surgery to remove a posterior mediastinal bronchogenic cyst, which was discovered on a computed tomography scan performed after an episode of pneumonia when traction bronchiectasis with interstitial lung disease/fibrosis was also suspected in the lungs. Histologic examination performed on the resected lung tissue revealed numerous scattered small osseous spicules on a background of intense interstitial inflammation and fibrosis, leading to further clinical and laboratory investigations and the final diagnosis of DPO secondary to lung involvement by scleroderma. Case 2 was an adult male patient who underwent thoracoscopic exploration after a computed tomography scan, which revealed traction bronchiectasis with linear thickening of the interstitial lung tissue. Histologic examination of the lung tissue specimen revealed numerous osseous spicules in the absence of interstitial septal inflammation. Noteworthy in this case were also some nodules of collagenized tissue similar to those seen in the lungs of patients affected by Ehlers-Danlos syndrome. The absence of any clinical sign or symptoms related to Ehlers-Danlos syndrome attest to the nonspecificity of these pulmonary fibrous nodules. No case of DPO secondary to scleroderma has been reported in the literature so far, although around half of the patients with scleroderma manifest pulmonary diseases. Idiopathic DPO is even rarer, usually discovered postmortem, with only 20 cases diagnosed in life with lung biopsies taken by open surgery or through a thoracoscopic approach. DPO is often misdiagnosed radiologically as bronchiectasis and/or interstitial lung disease/fibrosis.

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Heterotopic ossification in systemic sclerosis

Cited by 15 publications

References 18 publications

Heterotopic Ossification: A Comprehensive Review

Heterotopic Ossification: A Comprehensive Review

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

Selected Case From the Arkadi M. Rywlin International Pathology Slide Series

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