2010
DOI: 10.1167/iovs.10-5937
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Myosin Heavy Chain Expression in Mouse Extraocular Muscle: More Complex Than Expected

Abstract: MyHC isoforms have complex expression patterns, exhibiting not only longitudinal and cross-sectional variation of each isoform, but also of coexpression in single fibers. The highly heterogeneous MyHC expression reflects the complex contractile profiles of EOMs, which in turn are a function of the requirements of eye movements, which range from extremely fast saccades to sustained position, each with a need for precise coordination of each eye.

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Cited by 52 publications
(83 citation statements)
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References 21 publications
(31 reference statements)
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“…51 Variability in expression levels of IGF1 in strabismic muscles likely reflects variability in causes and/or phases of strabismus, 12 or a mismatch between gene expression and protein levels. 31,52 …”
Section: Discussionmentioning
confidence: 99%
“…51 Variability in expression levels of IGF1 in strabismic muscles likely reflects variability in causes and/or phases of strabismus, 12 or a mismatch between gene expression and protein levels. 31,52 …”
Section: Discussionmentioning
confidence: 99%
“…Although the unique anatomical and physiological features of EOMs have drawn much interest (Andrade et al, 2000; da Silva Costa et al, 2012; Spencer and Porter, 2006; Zhou et al, 2010), knowledge about the EOM myogenic progenitors is currently limited. One study that has used transgenic Pax7-nGFP mice for isolating and characterizing myogenic progenitors, placed the Pax7 + SCs as the main myogenic population in adult EOM as in the other muscles (Sambasivan et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…EOMs are skeletal muscles with unique properties, including patterns of gene expression very different from skeletal muscle and altered susceptibility to systemic myopathies. 1-5 …”
Section: Introductionmentioning
confidence: 99%