Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage

Abstract

Myosin binding protein H-like (MYBPHL) is a protein associated with myofilament structures in atrial tissue. The protein exists in two isoforms that share an identical amino acid sequence except for a deletion of 23 amino acids in isoform 2. In this study, MYBPHL was found to be expressed preferentially in atrial tissue. The expression of isoform 2 was almost exclusively restricted to the atria and barely detectable in the ventricle, arteria mammaria interna , and skeletal muscle. After atrial damage induced by cryo- or radiofrequency ablation, MYBPHL was rapidly and specifically released into the peripheral circulation in a time-dependent manner. The plasma MYBPHL concentration remained substantially elevated up to 24 hours after the arrival of patients at the intensive care unit. In addition, the recorded MYBPHL values were strongly correlated with those of the established biomarker CK-MB. In contrast, an increase in MYBPHL levels was not evident in patients undergoing aortic valve replacement or transcatheter aortic valve implantation. In these patients, the values remained virtually constant and never exceeded the concentration in the plasma of healthy controls. Our findings suggest that MYBPHL can be used as a precise and reliable biomarker to specifically predict atrial myocardial damage.

Mapping gene and gene pathways associated with coronary artery disease: a CARDIoGRAM exome and multi-ancestry UK biobank analysis

“…In addition, an-invitro study by Shen et al demonstrated upregulation of DUSP13 genes in cardiac myocytes in response to cadmium-induced cardiotoxicity 37 . In-vitro studies demonstrating the upregulation of MYBPHL and DUSP13 to cardiac stress and our gene-based analysis observations suggest their role in CAD pathophysiology 34 , 37 .…”

“…SNV (rs629001) in the MYBPHL gene has been reported as a non-synonymous coding variant by the Leducq Consortium CADGenomics investigators associated with CAD 33 . MYBPHL is myofilament protein overexpressed in human atrial tissue and its concentration increases in the serum after cryoablation or radiofrequency ablation induced atrial damage 34 . MYBPHL is also located in chromosome 1p13.3, which hosts other high-risk CAD loci 35 .…”

Proteomic Characterization of Senescent Laryngeal Adductor and Plantaris Hindlimb Muscles

“…2). 29,30 Eighteen proteins had an absolute z ‐score difference greater than 1.5 (Table II). Notable high‐abundant proteins in the plantaris relative to the thyroarytenoid included proteins involved in muscle structure and contraction (carbonic anhydrase 3 [CAH3], myosin regulatory light chain 2, ventricular/cardiac muscle isoform [MLRV], and myosin light chain 3 [MYL3]), and slow skeletal muscles troponin T [TNNT1] and troponin I [TNNI1]).…”

Aggrecan: a new biomarker for acute type A aortic dissection

“…Especially creatin kinase MB (CK-MB) and cardiac troponins (cTnTs) have a long history for the specific and sensitive detection of myocardial infarction (MI) 7 , 8 . In addition, we have recently described MYBPHL as a reliable biomarker to specifically predict damage of atrial tissue 9 . Although preliminary data suggest a possible role of plasma biomarkers, like smooth muscle derived calponins 10 , myosin heavy chain 11 or the fibrin fragment D-dimer 12 in early diagnosis of ATAAD, at present no reliable biomarker exists, to diagnose ATAAD with sufficient specificity and sensitivity.…”