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The CSI is a short, simple instrument that can be used in the clinical setting to quantify a patient's symptoms of chronic cough of upper airway origin. It represents a statistically reliable, valid, and clinically relevant instrument that can be used to measure treatment outcomes for chronic cough.

clinicaltrials.gov Identifier: NCT01255735.

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Retrospective studies, often considered inferior to prospective, randomized, and controlled clinical trials, can have strength and validity often not recognized in the hierarchy of clinical data.

Purpose This study aimed to examine the relationship between a large set of hypothesized physiological measures of vocal effort and self-ratings of vocal effort. Method Twenty-six healthy adults modulated speech rate and vocal effort during repetitions of the utterance /ifi/, followed by self-perceptual ratings of vocal effort on a visual analog scale. Physiological measures included (a) intrinsic laryngeal tension via kinematic stiffness ratios determined from high-speed laryngoscopy, (b) extrinsic suprahyoid and infrahyoid laryngeal tension via normalized percent activations and durations derived from surface electromyography, (c) supraglottal compression via expert visual–perceptual ratings, and (d) subglottal pressure via magnitude of neck surface vibrations from an accelerometer signal. Results Individual statistical models revealed that all of the physiological predictors, except for kinematic stiffness ratios, were significantly predictive of self-ratings of vocal effort. However, a combined regression model analysis yielded only 3 significant predictors: subglottal pressure, mediolateral supraglottal compression, and the normalized percent activation of the suprahyoid muscles (adjusted R 2 = .60). Conclusions Vocal effort manifests as increases in specific laryngeal physiological measures. Further work is needed to examine these measures in combination with other contributing factors, as well as in speakers with dysphonia.