Myonecrosis and Myoglobinuria in Alcohol and Barbiturate Intoxication

Alcohol and Skeletal Muscle in Health and Disease

“…5 More empirical reports that alcohol or its metabolites could directly or indirectly lead to adaptations of SKM mass and function and that there are differences with acute and chronic alcohol misuse were formulated in the 1950s and 1960s. 6 – 8 …”

“…5 More empirical reports that alcohol or its metabolites could directly or indirectly lead to adaptations of SKM mass and function and that there are differences with acute and chronic alcohol misuse were formulated in the 1950s and 1960s. [6][7][8] SKM mass is maintained by the balance of anabolic (protein synthesis) and catabolic (protein breakdown) signaling. Major anabolic stimuli-including amino acids, insulin, insulin-like growth factor 1 (IGF-1)-and mechanical loading promote protein synthesis by converging on the mechanistic/ mammalian target of rapamycin (mTOR) signaling pathway (reviewed by Bourgeois et al and Steiner et al ).…”