Myometrial prostaglandins during the human menstrual cycle

Vijayakumar, Ramana; Walters, William A. W.

doi:10.1016/s0002-9378(16)32639-4

Cited by 21 publications

(5 citation statements)

References 21 publications

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“…Suppression of this abnormal uterine activity enhances blood flow and reduces menstrual cramps and other symptoms that appear with dysmenorrhea. Results of this study showing increased levels of leukocytes during the di-estrous phase correlate with earlier reports of human menstrual phase characterized with endometrial leukocytes and increased myometrial prostaglandins (Vijayakumar & Walters, 1981;Salamonsen & Lathbury, 2000). It is therefore very possible that increased production and release of PGs reported during the human menstrual phase occurs during the di-estrous phase in female rats.…”

Section: Discussionsupporting

confidence: 89%

Comparative study of piroxicam and nitroglycerin on prostaglandin-modulated blood and electrolyte indices during di-estrous in female Wistar Rats

Adele¹,

Adebayo²,

Adewoye³

2022

JBRA

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Objective: Endogenous prostaglandins are involved in hemostasis, renal excretion of electrolytes, and implicated in dysmenorrhea. Piroxicam and Nitroglycerin are common drugs used in treating dysmenorrhea by inhibiting the cyclooxygenase pathway involved in prostaglandin production. However, studies comparing the effects of these drugs on prostaglandin-modulated hemostasis and renal function are lacking.Methods: Fifteen female rats (120-160g) were divided into 3 groups (20 per group), namely Control (distilled water, 0.3 mL), Piroxicam treated (3mg/kg) and Nitroglycerin treated (1 mg/kg). Di-estrous phase was confirmed in animals in each group using the Pipette smear method. Treatment was administered for 4 days covering the estrous cycle. Bleeding and clotting time were assessed and blood concentrations of sodium, potassium, urea and platelet counts were evaluated in all phases. Data were analyzed using one-way ANOVA and Newman-Keuls posthoc test. Statistical significance was considered at p<0.0.Results: The nitroglycerin-treated group showed significant increases in blood potassium during di-estrous while the piroxicam-treated group showed significant increases in blood potassium, urea and clotting time with a significant decrease in sodium levels during di-estrous compared to controls. Results obtained in other phases were not significant compared to controls. Conclusions:The study showed that Nitroglycerin produces minimum alteration of blood and electrolyte indices compared to piroxicam during di-estrous.

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Section: Discussionsupporting

confidence: 89%

Comparative study of piroxicam and nitroglycerin on prostaglandin-modulated blood and electrolyte indices during di-estrous in female Wistar Rats

Adele¹,

Adebayo²,

Adewoye³

2022

JBRA

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“…A low concentration of prostaglandins results in failure of ovulation, fertilization, decidualization and implantation in mice (Lim et al, 1997), but the exact role of prostaglandins in implantation in humans is not known. Prostaglandins in the myometrium increase during the late follicular phase, suddenly decrease after ovulation and reach a peak in the mid-luteal phase where the implantation window is situated (Vijayakumar and Walters, 1981).…”

Section: Discussionmentioning

confidence: 99%

Effect of piroxicam administration before embryo transfer on IVF outcome: a randomized controlled trial

Prato¹,

Borini²

2009

Reproductive BioMedicine Online

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Two hundred women aged between 28 and 43 years, with infertility from tubal, male, endometriosis or unexplained factor were randomly allocated into treatment (100 patients) and control (100 patients) groups. On the day after oocyte retrieval, each patient began supplementation with progesterone 8% vaginal gel, once daily. The patients in the treatment group received a single oral dose of 10 mg of the non-steroidal anti-inflammatory drug piroxicam 1-2 h before embryo transfer. No statistically significant difference was found between the two groups in any of the analysed endpoints. The rate of positive beta-human chorionic gonadotrophin test per transfer was 37% in the women treated with piroxicam and 47% in controls. The clinical pregnancy rate per transfer and implantation rate were 34% and 19.2% with piroxicam, 38% and 21.9% in controls. The miscarriage rate was 11.8% and 13.2%. No beneficial effect of piroxicam on pregnancy rates was found evaluating either different infertility causes or different ages. This study shows that the administration of a single dose of piroxicam before embryo transfer has no additional effect on pregnancy outcome in patients receiving adequate doses of progesterone for luteal phase supplementation after IVF or ICSI.

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“…Although the studies that specifically evaluate the effects of the Mediterranean-type diet on women fertility are scarce, different studies done on female experimental mammals suggested that the increased intake of vegetable oils that are rich in linoleic acid, an n -6 fatty acid, which can only be obtained by the diet, may improve the reproductive process. In fact, linoleic acid and others n -6 fatty acids, being precursors of the prostaglandins, might play an important role in the initiation of the menstrual cycle [ 398 ], growth, and development of pre antral follicles and ovulation [ 232 , 399 ], as like in the maintenance of pregnancy by optimizing endometrial receptivity [ 229 , 400 , 401 ]. Some studies showed that consuming n -6 PUFA instead of TFA was associated with a reduced risk of ovulatory infertility [ 402 ].…”

Section: The Beneficial Effects Of Mediterranean Diet For Women Hementioning

confidence: 99%

The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility

2016

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In female mammals, mechanisms have been developed, throughout evolution, to integrate environmental, nutritional and hormonal cues in order to guarantee reproduction in favorable energetic conditions and to inhibit it in case of food scarcity. This metabolic strategy could be an advantage in nutritionally poor environments, but nowadays is affecting women’s health. The unlimited availability of nutrients, in association with reduced energy expenditure, leads to alterations in many metabolic pathways and to impairments in the finely tuned inter-relation between energy metabolism and reproduction, thereby affecting female fertility. Many energetic states could influence female reproductive health being under- and over-weight, obesity and strenuous physical activity are all conditions that alter the profiles of specific hormones, such as insulin and adipokines, thus impairing women fertility. Furthermore, specific classes of nutrients might affect female fertility by acting on particular signaling pathways. Dietary fatty acids, carbohydrates, proteins and food-associated components (such as endocrine disruptors) have per se physiological activities and their unbalanced intake, both in quantitative and qualitative terms, might impair metabolic homeostasis and fertility in premenopausal women. Even though we are far from identifying a “fertility diet”, lifestyle and dietary interventions might represent a promising and invaluable strategy to manage infertility in premenopausal women.

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Myometrial prostaglandins during the human menstrual cycle

Cited by 21 publications

References 21 publications

Comparative study of piroxicam and nitroglycerin on prostaglandin-modulated blood and electrolyte indices during di-estrous in female Wistar Rats

Comparative study of piroxicam and nitroglycerin on prostaglandin-modulated blood and electrolyte indices during di-estrous in female Wistar Rats

Effect of piroxicam administration before embryo transfer on IVF outcome: a randomized controlled trial

The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility

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