Myometrial Invasion in Endometrial Cancer: Diagnostic Accuracy of Diffusion-weighted 3.0-T MR Imaging—Initial Experience

Lin, Gigin; Ng, Koon‐Kwan; Chang, Chee‐Jen; Wang, Jiun‐Jie; Ho, Keang-Po; Yen, Tzu-Chen; Wu, Tingqing; Wang, Chun‐Chieh; Chen, Yu-Ruei; Huang, Yu‐Ting; Ng, Shu‐Hang; Jung, Shih‐Ming; Chang, Ting‐Chang; Lai, Chyong‐Huey

doi:10.1148/radiol.2503080874

Cited by 161 publications

(111 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…WbT2/wbDWI image fusion shows significantly higher detection rates compared with wbT2 and wbDWI alone, which parallels findings from retrospective image fusion studies of DWI and T2-weighted image data [31][32][33]. However, these studies did not evaluate side-by-side analysis.…”

Section: Discussionsupporting

confidence: 60%

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

et al. 2010

View full text Add to dashboard Cite

Objective To prospectively evaluate the diagnostic accuracy of whole-body T2-weighted (wbT2), whole-body diffusion-weighted imaging (wbDWI) and wbT2/wbDWI image fusion for malignant tumour detection compared with PET/CT. Methods Sixty-eight patients (44 men; 60±14 years) underwent PET/CT for staging of malignancy and were consecutively examined by 1.5-Tesla MRI including wbT2 and wbDWI. Two radiologists independently assessed wbDWI, wbT2, wbT2 + wbDWI (side-by-side) and wbT2 + wbDWI + wbT2/wbDWI image fusion for the presence of malignancy. PET/CT served as a reference standard. Results PET/CT revealed 374 malignant lesions in 48/64 (75%) patients. Detection rates and positive predictive value (PPV) of wbT2 and wbDWI alone were 64% and 84%, and 57% and 93%, respectively. Detection rates and PPV of wbT2 and wbDWI for side-by-side analysis without and with fused images were 72% and 89%, and 74% and 91%, respectively. The detection rate was significantly higher with side-by-side analysis and fused image analysis compared with wbT2 and wbDWI alone (p = .0159; p<.0001). There was no significant difference between fused image interpretation and side-by-side analysis. Conclusions WbDWI allows detection of malignant lesions with a similar detection rate to wbT2. Side-by-side analysis of wbT2 and wbDWI significantly improves the overall detection rate and fused image data provides no added value.

show abstract

Section: Discussionsupporting

confidence: 60%

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

et al. 2010

View full text Add to dashboard Cite

show abstract

“…3 Das SK et al in their meta-analysis of usefulness of DWI in endometrial cancer patients found sensitivity and specificity for detection of deep myometrial invasion to be 90% and 89% respectively. 4 They concluded that DWI offered potential advantages over Dynamic Contrast enhanced MRI as it did not involve use of intravenous contrast which would be contraindicated in patients with renal impairment.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of MR Imaging in endometrial cancer: our experience

Sampath

Nema

Agarwal

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: MRI is a useful modality for preoperative imaging in endometrial cancer. We report our experience in Indian population managed at a tertiary care center regarding accuracy of preoperative MRI in prediction of deep myometrial invasion and cervical stromal invasion.Methods: 30 patients with endometrioid adenocarcinoma endometrium on endometrial biopsy underwent preoperative MRI in the week preceding surgery. MRI impression of depth of myometrial invasion, cervical stroma involvement and positive nodes were compared with final histopathology findings to calculate the accuracy of MRI.Results: The accuracy of MRI for estimation of tumour size was 72% and for detection of myometrial invasion was 76%. The accuracy for detection of cervical, adnexal and nodal involvement was 96%, 100% and 96% respectively.Conclusions: MRI is an accurate modality for preoperative assessment in endometrial cancer and can significantly assist in surgical planning.

show abstract

“…MRI, has allowed correct evaluation of myometrial invasion in cases complicated by adenomyosis and other factors that make the evaluation dif cult 28 .…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of Diffusion-weighted Imaging in Observing Localized Extension of Endometrial Cancer

Bell

Yagi

Hatano

et al. 2014

Showa Univ J Med Sci

View full text Add to dashboard Cite

: Endometrial cancer is the seventh most common human malignancy and the most common form of cancer treated in women by obstetrics and gynecology departments. Until now, magnetic resonance imaging MRI has been used for pre-surgical evaluation of endometrial cancer and evaluating the depth of myometrial invasion, in addition to being a valuable diagnostic tool. Diffusion-weighted imaging DWI has been reported as useful in distinguishing between benign and malignant tumors when observing lesions in the endometrium. Subsequent reports suggest that DWI is also effective in identifying malignancy and diagnosing local extension in a range of tissues. Based on this, we implemented a study of the effectiveness of DWI in identifying local extension of endometrial cancer. This study enrolled patients undergoing surgery at this hospital for cancer of the uterine body during the six years from January 2008 to February 2014. Cases in which images were unclear or the lesions were too small to be described by MRI examination were excluded, leaving 61 patients in the study. Using the results from pre-surgical MRI, a sequence comprising a T2-weighted axial view alone and a T2-weighted axial view to which a diffusion-weighted axial view had been added was created for each patient. Two radiologists then independently examined the image sequence to determine localized extension. Following surgery, the presurgical assessment was compared to the localized extension determined by histopathology of post-surgical samples to evaluate the effectiveness of adding diffusionweighted imaging to the process. The rst radiographic interpreter s rate of correct diagnosis using the T2-weighted axial view alone was 45 out of 55 cases 81.8 , while using the T2-weighted axial view to which a diffusion-weighted axial view had been added gave a correct diagnosis rate of 51 out of 55 cases 92.7 . The second radiographic interpreter s rate of correct diagnosis using the T2-weighted axial view alone was 41 out of 55 cases 74.5 , while using the T2-weighted axial view with diffusion-weighted axial view added gave a correct diagnosis rate of 51 out of 55 cases 92.7 . These differences were statistically signi cant based on the McNemar testing. This study con rmed that DWI is an effective means of diagnosing localized extension from images. It is anticipated that DWI will be used in the future clinical workplace to provide more accurate pre-surgical diagnoses.

show abstract

Myometrial Invasion in Endometrial Cancer: Diagnostic Accuracy of Diffusion-weighted 3.0-T MR Imaging—Initial Experience

Abstract: Fused T2-weighted and high-b-value DW images at 3 T can provide accurate information for preoperative evaluation of myometrial invasion.

Cited by 161 publications

References 22 publications

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT

Accuracy of MR Imaging in endometrial cancer: our experience

The Usefulness of Diffusion-weighted Imaging in Observing Localized Extension of Endometrial Cancer

Contact Info

Product

Resources

About