Myokardschädigung und Paroxysmale Ventrikuläre Tachykardie bei einem Hund nach Albuterolintoxikation

Abstract

Intoxication with the beta2-agonist Albuterol may lead to immediate signs of beta-adrenergic stimulation like excitation, tachypnea and tachycardia. Furthermore, it typically causes severe hypokalemia, which then leads to muscle weakness and which predisposes to ventricular arrhythmias. We describe a dog where albuterol intoxication caused runs of fast paroxysmal ventricular tachycardia that persisted after normalization of the hypokalemia. Based on a markedly elevated serum troponin I level acute myocardial damage was identified as cause of the tachyarrhythmia. Repeated Troponin I measurements and Holter-ECGs were the means to document complete cure.

Retrospective evaluation of acute salbutamol (albuterol) exposure in dogs: 501 cases

“…It is worth noting that in this case the diagnosis was made with a long-term Holter ECG and may not have been identified with a short ECG strip. 12 No similar cases were reported in this case series, but few dogs had an ECG measured and none had the troponin concentration measured.…”

“…8,11 Propranolol is preferred over atenolol because it is not selective for β1 receptors but will act on both β1 and β2 and will help control systemic signs, hypokalemia, and cardiac effects. 12 Propranolol and atenolol were the most commonly used beta-blockers in this case series (57.6% and 38.4% of cases, respectively, where a beta-blocker was used). Esmolol was used in 2 dogs: in 1 case after propranolol was ineffective, and in the other case the esmolol was ineffective and propranolol was used instead.…”