Myokardnekrosen nach permanentem oder temporärem Koronararterienverschluß mit und ohne Herzentlastung durch extrakorporale Zirkulation

Krug, A

doi:10.1007/bf02120615

Cited by 6 publications

(1 citation statement)

References 103 publications

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“…This might suggest, as one might perhaps expect, that it is in those areas of less pronounced ischaemia that the benefits of P-blockade are most clearly seen. Certainly in this model there is histological evidence of irreversible injury, leading to cell necrosis, at the time (1 h) after occlusion when, in these experiments, exaprolol was given (Krug, 1972). It could be therefore that earlier intervention would have been even more effective.…”

Section: Discussionmentioning

confidence: 99%

The effect of exaprolol (MG 8823) on epicardial ST‐segment changes in a feline model of acute myocardial ischaemia

Parratt

Udvary

1983

British J Pharmacology

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3 Exaprolol (1.0mg kg-, intravenously) a potent P-adrenoceptor blocking agent with 'membrane stabilising activity', when given 1 h after the onset of ischaemia, reduced heart rate and LV dP/dt,, and increased LVEDP. These effects were prolonged (i.e. little recovery in heart rate 3 h after administration). 4 Exaprolol decreased total ST-segment elevation immediately after administration; this was significantly different from the effect of intravenous saline and lasted for at least 3 h. The effects appeared to be greater at sites of less pronounced ischaemia. 5 Intramyocardial temperature records were taken to indicate a reduction in blood flow to the ischaemic region; however the alleviation of epicardial ST-segment elevation suggests an improved myocardial oxygen demand: supply ratio. 6 Reperfusion was unsuccessfully attempted after a 4 h occlusion period; reperfusion after a shorter period (30 min) resulted in ventricular ectopic activity but no fibrillation.

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Section: Discussionmentioning

confidence: 99%