Myoinositol in Autoimmune Thyroiditis

Paparo, Sabrina Rosaria; Ferrari, Silvia; Patrizio, Armando; Elia, Giusy; Ragusa, Francesca; Botrini, Chiara; Balestri, Eugenia; Guarneri, Fabrizio; Benvenga, Salvatore; Antonelli, Alessandro; Fallahi, Poupak

doi:10.3389/fendo.2022.930756

Cited by 12 publications

(13 citation statements)

References 50 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some intervention studies performed in adult non-pregnant subjects showed that a myo-inositol (in association with selenium) supplementation was able to decrease TSH and anti-thyroid antibodies titers in patients with chronic autoimmune thyroiditis [117]. Nevertheless, these results should be confirmed by larger RCTs [116,118].…”

Section: Myo-inositolmentioning

confidence: 96%

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Pinto

Croce

Carlier

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose Gestational diabetes mellitus (GDM) and thyroid dysfunction during gestation (GTD) are the two most prevalent endocrinopathies during pregnancy. The aim of the present review is to provide an overview of the peculiar aspects of GDM and GTD, to highlight the potential interactions and clinical consequences of these two frequent clinical conditions. Methods A literature review regarding GDM and GTD was carried out with particular interest on meta-analyses and human studies dealing with the (i) shared risk factors between GDM and GTD, (ii) the epidemiological link between GTD and GDM, (iii) physiopathologic link between GTD and GDM, (iv) clinical consequences of GDM and GTD, and (v) post-partum implications of GDM and GTD. Results The association between GDM and GTD is common and may be explained by the insulin-resistance state due to maternal GTD, to alterations in the placentation process or to the many shared risk factors. Discrepant results of epidemiologic studies can be explained, at least in part, by the changes in diagnostic criteria and screening strategies throughout the years for both conditions. GDM and GTD impact pregnancy outcome and have post-partum long-term consequences, but more studies are needed to prove an additional adverse effect. Conclusions Based on the epidemiological and physio-pathological link between GDM and GTD, it could be suggested that a diagnosis of GTD could lead to screen GDM and the other way round.

show abstract

Section: Myo-inositolmentioning

confidence: 96%

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Pinto

Croce

Carlier

et al. 2023

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…AITD patients overexpress certain inflammatory factors through exosomes, leading to an increase in serum TPOAb and TgAb levels, thereby affecting the occurrence and development of AITD ( 49 , 50 ). Myoinositol (Myo) has also been found to have beneficial effects on AITD ( 51 ). The emergence of AITD is accompanied by changes in various pathogenic factors.…”

Section: Discussionmentioning

confidence: 99%

Global scientific trends on thyroid disease in early 21st century: a bibliometric and visualized analysis

Song,

Sun,

Liu

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundBibliometrics has been used to analyze the literature in the field of thyroid disease studies in the early 21st century, indicating the changes in current international study trends.MethodsIn this study, a bibliometric analysis of data retrieved from the Web of Science (WoS) database was conducted, and the publication trends and thematic evolution in the field of thyroid disease research from January 1, 2000, to November 16, 2022, were analyzed. A total of 69283 articles related to thyroid diseases were evaluated for their characteristics, including annual publication volume, countries, journals, institutions, authors, keywords, and references. VOSviewer was utilized to perform the analysis of co-authorship, co-citation, co-occurrence and descriptive.ResultsThe annual publication volume of thyroid disease research literature showed a fluctuating upward trend from 2000 to 2021, exceeding 5,000 articles for the first time in 2021. The United States (16120 counts, 678255 cities) ranks first in terms of publication volume and citation. Thyroid (n=3201) and Journal of Clinical Endocrinology&Metabolism (n=140399) are the most prolific and cited journals, respectively. The organization with the highest publication volume and citation frequency is Harvard University (1011 counts, 59429 cities), Miyauchi Akira (n=422), Schlumberger, and Martin (n=24839) possess the highest publication volume and citation frequency, respectively. Co-occurrence analysis of 307 keywords with frequencies of more than 20 resulted in 6 clusters (1): Thyroid dysfunction and diseases (2); mechanism of occurrence and development of thyroid cancer (3); autoimmune thyroiditis (4); scope and postoperative management of thyroid surgery (5); fine needle aspiration of thyroid nodules (6); radioactive iodine therapy for thyroid cancer. Active monitoring, thermal ablation, Lenvatinib, and long noncoding RNA refer to the latest keywords. Discussing the six clusters helps scholars to determine the scope and direction of studies.ConclusionOver the past two decades, the literature related to thyroid diseases has increased year by year, with closer collaboration between countries, institutions, and authors. In this study, the global trends, research hotspots, emerging subjects, and basic knowledge of literature related to thyroid diseases were respectively elucidated, which will facilitate researchers in this field to seek better development.

show abstract

“…Myo is involved in the TSH signaling pathway; thus, depleted levels of Myo may cause the pathogenesis of thyroid diseases such as hypothyroidism ( 187 ). It has been observed that TSH levels significantly decreased in patients with subclinical hypothyroidism, with or without autoimmune thyroiditis, after treatment with Myo in combination with selenium ( 201 , 202 ). Studies of patients with Hashimoto’s thyroiditis and subclinical hypothyroidism showed that supplementation of Myo and selenomethionine significantly decreased TSH, TPOAb, and TGAb concentrations, while simultaneously increasing thyroid hormones levels and restoring euthyroid state in patients with autoimmune thyroiditis ( 203 , 204 ).…”

Section: Nutritional Antioxidants and Thyroid Diseasementioning

confidence: 99%

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

et al. 2023

View full text Add to dashboard Cite

An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases.

show abstract

Myoinositol in Autoimmune Thyroiditis

Cited by 12 publications

References 50 publications

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Global scientific trends on thyroid disease in early 21st century: a bibliometric and visualized analysis

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Contact Info

Product

Resources

About