Myoinhibitory neuropeptides in the American cockroach☆

Predel, Reinhard; Rapus, Jürgen; Eckert, Manfred

doi:10.1016/s0196-9781(00)00383-1

Cited by 106 publications

(108 citation statements)

References 31 publications

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“…The two Drome-MS receptors have an EC 50 for Drome-MS of 4 ϫ 10 Ϫ8 M. This value compares well with the concentrations of Drome-MS needed in pharmacological or physiological ex- (20), and with the concentrations of other insect myosuppressins that were used to inhibit the blowfly crop (4 ϫ 10 Ϫ8 M) (19), the cockroach fore-and hindgut (between 10 Ϫ10 M and 3 ϫ 10 Ϫ8 M) (9,14), the locust heart (EC 50 , 5 ϫ 10 Ϫ8 M) (13), or the salivary gland from Rodnius prolixus (between 5 ϫ 10 Ϫ9 and 5 ϫ 10 Ϫ7 M) (18). These data, therefore, suggest that the two cloned Drome-MS receptors are the physiologically relevant myosuppressin receptors.…”

Section: Discussionsupporting

confidence: 56%

“…These neuropeptides have first been isolated from cockroaches and later from locusts, flies, and moths and it can be anticipated that they occur in all insects (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The myosuppressins obtained their name because they have a general inhibitory action on a variety of visceral muscles from insects (1)(2)(3)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Because the insect myosuppressins also block the visceral muscles involved in the passage of food along the alimentary canal (2,9,12,(15)(16)(17)19), they have attracted the interest of researchers that are aiming to develop nonpeptide agonists of myosuppressin receptors to use them as insecticides.…”

mentioning

confidence: 99%

“…The myosuppressins obtained their name because they have a general inhibitory action on a variety of visceral muscles from insects (1)(2)(3)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Because the insect myosuppressins also block the visceral muscles involved in the passage of food along the alimentary canal (2,9,12,(15)(16)(17)19), they have attracted the interest of researchers that are aiming to develop nonpeptide agonists of myosuppressin receptors to use them as insecticides. On several occasions, one compound, benzethonium chloride, has been claimed to be such a myosuppressin receptor agonist (14,19,21).…”

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confidence: 99%

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Molecular cloning and functional expression of the first two specific insect myosuppressin receptors

Egerod

Reynisson

Hauser

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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The Drosophila Genome Project database contains the sequences of two genes, CG8985 and CG13803, which are predicted to code for G protein-coupled receptors. We cloned the cDNAs corresponding to these genes and found that their gene structures had not been correctly annotated. We subsequently expressed the coding regions of the two corrected receptor genes in Chinese hamster ovary cells and found that each of them coded for a receptor that could be activated by low concentrations of Drosophila myosuppressin (EC 50 , 4 ؋ 10 ؊8 M). The insect myosuppressins are decapeptides that generally inhibit insect visceral muscles. Other tested Drosophila neuropeptides did not activate the two receptors. In addition to the two Drosophila myosuppressin receptors, we identified a sequence in the genomic database from the malaria mosquito Anopheles gambiae that also very likely codes for a myosuppressin receptor. To our knowledge, this paper is the first report on the molecular identification of specific insect myosuppressin receptors.

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Section: Discussionsupporting

confidence: 56%

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confidence: 99%

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confidence: 99%

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Molecular cloning and functional expression of the first two specific insect myosuppressin receptors

Egerod

Reynisson

Hauser

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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“…The FGLa/ASTs inhibit spontaneous and proctolin-induced gut contraction (Lange et al, 1993;Lange et al, 1995;Duve et al, 1995;Sarkar et al, 2003;Fusé et al, 1999). The MIPs (also known as B-type ASTs) were originally named because of their inhibition of hindgut and oviducal contractions in the locust (Schoofs et al, 1991) and members of this family inhibit gut contraction in other insect species, including cockroaches (Predel et al, 2001) (see Audsley and Weaver, 2009). While the FGLa/ASTs inhibit gut contraction, the allatotropins stimulate gut contraction in several insect species including moths (see Spit et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson

Rodriguez

Lange

2012

Journal of Experimental Biology

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“…MIPs are a set of highly conserved peptides that have been identified or predicted in many different insect species (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Interestingly, however, MIPs, like SPR, cannot be detected in the sequenced hymenoptera genomes (Fig.…”

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confidence: 99%

MIPs are ancestral ligands for the sex peptide receptor

Kim

Bartalska

Audsley

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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238

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Upon mating, females of many animal species undergo dramatic changes in their behavior. In Drosophila melanogaster, postmating behaviors are triggered by sex peptide (SP), which is produced in the male seminal fluid and transferred to female during copulation. SP modulates female behaviors via sex peptide receptor (SPR) located in a small subset of internal sensory neurons that innervate the female uterus and project to the CNS. Although required for postmating responses only in these female sensory neurons, SPR is expressed broadly in the CNS of both sexes. Moreover, SPR is also encoded in the genomes of insects that lack obvious SP orthologs. These observations suggest that SPR may have additional ligands and functions. Here, we identify myoinhibitory peptides (MIPs) as a second family of SPR ligands that is conserved across a wide range of invertebrate species. MIPs are potent agonists for Drosophila, Aedes, and Aplysia SPRs in vitro, yet are unable to trigger postmating responses in vivo. In contrast to SP, MIPs are not produced in male reproductive organs, and are not required for postmating behaviors in Drosophila females. We conclude that MIPs are evolutionarily conserved ligands for SPR, which are likely to mediate functions other than the regulation of female reproductive behaviors.Drosophila | female post-mating behavior | G protein-coupled receptor | neuropeptide | neuromodulation P eptide signaling through G protein-coupled receptors is a widely used mechanism for reversibly modulating the behavioral output of innate neural circuits (for review see ref. 1). A prominent example of peptidergic modulation of behavior is the regulation of female reproductive behavior in Drosophila melanogaster by the male's sex peptide (SP). SP is a small peptide present in the male seminal fluid. Upon mating, SP is transferred to the female, where it triggers dramatic changes in reproductive and other behaviors (2, 3). These behavioral modifications typically last for about a week, the period for which the female is able to store and use sperm from the initial mating (for review see ref. 4). Within females, SP is thought to activate a specific G protein-coupled receptor (SPR) (5) in a small set of internal sensory neurons of the female reproductive tract (6, 7). Signaling by SP and SPR is essential for the modulation of female behavior as these changes do not occur if the male lacks SP (8, 9) or the female lacks SPR (5).The modulation of female reproductive behavior in response to SP (and its closely related homolog DUP99B) (10, 11) is currently the only known role of SPR. Nonetheless, several lines of evidence have hinted that SPR may have other ligands and possibly also other functions. First, SPR is broadly expressed throughout the central nervous system (5), yet it is required only in reproductive tract sensory neurons for the postmating behavioral switch (6, 7). Second, SPR is also expressed in the central nervous system of males (5), where it is not likely to be exposed to SP. Third, orthologs of SPR are clearly d...

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Myoinhibitory neuropeptides in the American cockroach☆

Cited by 106 publications

References 31 publications

Molecular cloning and functional expression of the first two specific insect myosuppressin receptors

Molecular cloning and functional expression of the first two specific insect myosuppressin receptors

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

MIPs are ancestral ligands for the sex peptide receptor

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