Myogenic differentiation factor 1 and myogenin expression not elevated in regenerated masticatory muscles of dystrophic (mdx) mice

Abstract

The results indicate that protein expression of MyoD1 and myogenin in mdx mice does not differ from controls, suggesting a secondary role of MyoD1 and myogenin in the regeneration stage of mdx orofacial muscles.

Expression rate of myogenic regulatory factors and muscle growth factor after botulinum toxin A injection in the right masseter muscle of dystrophin deficient (mdx) mice

“…40 Compared to controls, a significantly reduced MSTN expression could have recently been observed in the masticatory muscles of 100-day-old dystrophic mice. 21 In the complete regenerated muscle in the mdx mouse after 9 weeks of birth, there was no evidence of myostatin. 40 Based on our findings, one can act on the assumption that regenerative processes in the masticatory muscles of the mdx mouse after BTX-A injection in the right masseter muscle were highly activated in these mice, which usually cannot be found at this age.…”

“…20 The same could be demonstrated for the expression of myogenin and MyoD1 protein in the masticatory muscles of 100-day-old dystrophic mice compared to the controls. 21 For this reason, the present study was performed using 100-day-old control and mdx mice. On the 4 th day after BTX-A injection, by means of gene expression in the right masseter muscle, it could be concluded that the full effect of muscle paralysis was obtained.…”