Myogenic cells in Kaposi's sarcoma: An ultrastructural study

Harrison, A. C.; Kahn, Leonard B.

doi:10.1002/path.1711240305

Cited by 51 publications

(12 citation statements)

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“…1). However, when PAF was measured after 48 h of growth without FCS in (8)(9)(10)(11)(12). We thus studied the effect of PAF on the migration and proliferation of KS cells, EC, VSMC, and macrophage murine cell line J774.…”

Section: Resultsmentioning

confidence: 99%

“…The ontogenetic origin of KS has not been unequivocally defined (8)(9)(10)(11)(12). Spindle cells represent the core of the lesion and consist of at least two populations, one expressing fibro-endothelial markers and the other a phenotype typical of monocytoid cells (11).…”

Section: Discussionmentioning

confidence: 99%

“…The early phase of disease is characterized by an infiltrate of leukocytes and a prominent angiogenesis, which is crucial to the growth and progression of KS (8)(9)(10)(11)(12). The current hypothesis to explain the behavior of KS is an imbalance in the network of soluble mediators caused by HIV-1, other viruses, immunosuppressive treatment, or genetic factors (13)(14)(15)(16)(17)(18).…”

mentioning

confidence: 99%

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Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Bussolino¹,

Arese

Montrucchio³

et al. 1995

J. Clin. Invest.

100

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Bussolino¹,

Arese

Montrucchio³

et al. 1995

J. Clin. Invest.

100

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“…In one study, no pericytes were identified, although cells with smooth muscle differentiation were noted. 8 We believe that these are more appropriately interpreted as pericytes rather than smooth muscle cells.…”

Section: Discussionmentioning

confidence: 97%

Kaposi's sarcoma in renal transplant recipients ultrastructural and immunoperoxidase study of four cases

Akhtar

Bunuan

Ali

et al. 1984

Cancer

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Tissues from four cases of Kaposi's sarcoma developing in renal transplant recipients were studied by light and electron microscopic examination and by immunoperoxidase staining for Factor‐VIII‐related antigen. Ultrastructurally, the tumors in all four cases contained a variable mixture of cells, including endothelial cells, pericytes, fibroblasts, and myofibroblasts. These findings support the origin of Kaposi's sarcoma from primitive vasoformative mesenchyme. Immunoperoxidase staining for Factor‐VIII‐related antigen was limited to endothelial cells. In one case intracytoplasmic virus‐like tubular complexes were seen. The significance of this finding is briefly discussed.

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“…According to the published literatures, the majority of pediatric cases of KS in Equatorial Africa initially occurred in the lymph node and often showed a generalized lymphadenopathy (Dutz and Stout, 1960 (Pepler, 1959), mesenchymal cell (Harrison and Kahn, 1978) or fibroblast (Mottaz and Zelickson, 1966;Nickoloff and Griffiths, 1989). However, the cell origin of KS remains unknown.…”

mentioning

confidence: 99%

Geopathology of endemic pediatric lymph node Kaposi's sarcoma in Western Kenya.

Komuro

Toriyama

1991

Jap. J. Trop. Med. Hyg.

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Abstract:We conducted an epidemiological and histological analysis of the endemic lymph node-type Kaposi's sarcoma (KS) in African children (under 16 years old) in Western Kenya in order to determine the ethno-geographical distribution of the disease and to clarify its histological features and histogenesis during the 12-year period between 1979 to 1990. The age distribution of all endemic type KS in Western Kenya showed two age peaks; one in early childhood and the other in middle to advanced age. Most endemic KS in children initially occurred in the lymph nodes, while that of people of middle to advanced age showed a primary lesion in the skin. The male to female ratio of the endemic KS was 3.1 to 1 (in all pediatric types), 3.4 to 1 (in the pediatric lymph node-type) and 10.8 to 1 (in all adult types). A high incidence of the lymph node-type KS in children was observed in the Luo group ethnically and in Nyanza Province around Lake Victoria geographically. The lymph node-type KS originated at the paracortical areas and gradually grew along the reticulin network originating from the trabeculae. The lesion of KS histologically consisted of several types of cells, especially spindle-shaped cells, macrophage-like cells and immature endothelial cell-like cells and was accompanied by almost normal small blood vessels, lymphatic vessels and postcapillary venules. No abnormal mitoses were observed in any of the cells. There were no primary necroses due to tumor proliferation and also no extracapsular invasions. Immunohistochemically, spindle-shaped cells, immature endothelial cell-like cells and mature endothelial cells were positive for Vimentin, but only mature endothelial cells were positive for Factor-VII IRa and UEA -1. Macrophage-like cells were positive for Factor-XII IRa. These findings suggested that: 1) there are certain differences in the etiological co-factors of KS between the endemic lymph node-type KS in children and the endemic cutaneous type KS in adults, 2) KS cells originate from pluripotent mesenchymal cells and 3) KS might not be a malignant tumor, but rather a benign neoplasm, tumor-like lesion or reactive hyperplasia.

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Myogenic cells in Kaposi's sarcoma: An ultrastructural study

Cited by 51 publications

References 12 publications

Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Kaposi's sarcoma in renal transplant recipients ultrastructural and immunoperoxidase study of four cases

Geopathology of endemic pediatric lymph node Kaposi's sarcoma in Western Kenya.

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