Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?

Coletta, Ricardo D.; Salo, Tuula

doi:10.1111/odi.12694

Cited by 17 publications

(18 citation statements)

References 33 publications

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“…The previous study demonstrated that ACTA2 is associated with cancer associated fibroblasts in various tumors including pancreatic ductal adenocarcinoma, invasive breast cancer, and oral cancer. There is also evidence that ACTA2 participates in the BP of the TGF‐β signaling pathway (Casey et al, ; Coletta & Salo, ; Öhlund et al, ). Functional analysis validated that ACTA2 was associated with extracellular space, mesenchyme migration, and extracellular exosome.…”

Section: Discussionmentioning

confidence: 99%

The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets

Zhou

Song

et al. 2019

Journal Cellular Physiology

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Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years. Available biomarkers are not sensitive enough for the diagnosis of BC, whereas the standard diagnostic method, cystoscopy, is an invasive test and expensive. Hence, seeking new biomarkers of BC is urgent and challenging. With that order, we screened the overlapped differentially expressed genes (DEGs) of GSE13507 and TCGA BLCA datasets. Subsequent protein–protein interactions network analysis recognized the hub genes among these DEGs. Further functional analysis including Gene Ontology and KEGG pathway analysis and gene set enrichment analysis were processed to investigate the role of these genes and potential underlying mechanisms in BC. Kaplan–Meier analysis and Cox hazard ratio analysis were carried out to clarify the diagnostic and prognostic role of these genes. In conclusion, our present study demonstrated that ACTA2, CDC20, MYH11, TGFB3, TPM1, VIM, and DCN are all potential diagnostic biomarkers for BC. And may also be potential treatment targets for clinical implication in the future.

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Section: Discussionmentioning

confidence: 99%

The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets

Zhou

Song

et al. 2019

Journal Cellular Physiology

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“…The phenotypic alterations at the level of the alpha smooth muscle actin of CAFs result in increased desmoplasia at the TME ECM [14]. The consequences of CAFs induced desmoplasia are generally related with tumor progression and metastasis in breast, oral, ovarian and pancreatic cancers [25,122,123,124].…”

Section: Targeting the Tumor Microenvironmentmentioning

confidence: 99%

Targeting Tumor Microenvironment for Cancer Therapy

Roma‐Rodrigues

Mendes

Baptista

et al. 2019

IJMS

867

683

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Cancer development is highly associated to the physiological state of the tumor microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from different anatomical locations, common features can be found in the TME maturation of epithelial-derived tumors. Genetic alterations in tumor cells result in hyperplasia, uncontrolled growth, resistance to apoptosis, and metabolic shift towards anaerobic glycolysis (Warburg effect). These events create hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes and macrophages), inducing angiogenesis and, ultimately, resulting in metastasis. Exosomes secreted by TME cells are central players in all these events. The TME profile is preponderant on prognosis and impacts efficacy of anti-cancer therapies. Hence, a big effort has been made to develop new therapeutic strategies towards a more efficient targeting of TME. These efforts focus on: (i) therapeutic strategies targeting TME components, extending from conventional therapeutics, to combined therapies and nanomedicines; and (ii) the development of models that accurately resemble the TME for bench investigations, including tumor-tissue explants, “tumor on a chip” or multicellular tumor-spheroids.

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“…The histopathological classification of oral epithelial dysplasia can assist in the monitoring and definition of the most appropriate treatment; however, other factors may be determinant in the process of malignant transformation (34,35). Several biomarkers are being analyzed by immunohistochemistry in order to evaluate their participation in oral epithelial dysplasia (3,6). In clinicopathological practice, immunohistochemistry is relatively easy to apply and more accessible than other techniques.…”

Section: Discussionmentioning

confidence: 99%

“…The potential of malignant transformation is believed to be related to the degree of epithelial dysplasia observed (2)(3)(4). Several studies have been conducted to identify possible markers that can trigger the development of OPMDs as well as predict their progression (2,5,6). The epithelial-mesenchymal transition (EMT) is a mechanism frequently dysregulated in cancer (5)(6)(7)(8)(9)(10)12).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have been conducted to identify possible markers that can trigger the development of OPMDs as well as predict their progression (2,5,6). The epithelial-mesenchymal transition (EMT) is a mechanism frequently dysregulated in cancer (5)(6)(7)(8)(9)(10)12). However, studies evaluating the role of EMT in the development/progression of dysplastic processes in oral epithelium are scarce.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

Morais

Pinheiro²,

Lira³

et al. 2020

Med Oral

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Background: Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. Material and Methods: A systematic search was performed in the following databases: PubMed, EMBASE, Chinese BioMedical Literature Database, and Cochrane Library. Articles that evaluated the relationship between the expression of EMT markers and the degree of oral epithelial dysplasia were selected for the systematic review. The quality of each eligible study was evaluated by independent reviewers that used operationalized prognostic biomarker reporting guidelines (REMARK). Results: Seventeen articles met all inclusion criteria and were selected. The EMT markers analyzed exhibited an important association with the prognosis of the cases evaluated. The results showed a progressive increase in the expression of nuclear transcription factors and markers of mesenchymal differentiation, as well as negative regulation of epithelial and cell adhesion markers, according to the stage of oral epithelial dysplasia.

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Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?

Cited by 17 publications

References 33 publications

The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets

The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets

Targeting Tumor Microenvironment for Cancer Therapy

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: A systematic review

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