Myofibroblastoma of the breast: Case report and literature review

Mele, Marco; Jensen, Viggo A.; Wronecki, Adam Jan; Lelkaitis, Giedrius

doi:10.1016/j.ijscr.2011.02.006

Cited by 36 publications

(56 citation statements)

References 17 publications

(11 reference statements)

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“…Histopathologically classic, cellular, collagenous / fibrous, lipomateous, infiltrative, myxoid, epithelioid, and decidua-like variants have been identified (2). On immunohistochemical evaluation, MFB typically stains positive with CD34 and vimentin, desmin, SMA, and displays variable staining with CD99 and bcl-2.…”

Section: Discussionmentioning

confidence: 99%

“…Toker et al first defined it in 1981 (1). It is seen in both sexes at older age (2). Several subtypes of MFB have been defined such as; classic, cellular, collagenous / fibrous, lipomateous, infiltrative, myxoid, epithelioid, and decidua-like variant (2).…”

Section: Introductionmentioning

confidence: 99%

“…Several subtypes of MFB have been defined such as; classic, cellular, collagenous / fibrous, lipomateous, infiltrative, myxoid, epithelioid, and decidua-like variant (2). Clinically they are often mistaken for fibroadenoma and hamartomas since they have a regular and non-invasive appearance on mammography and breast ultrasound (2). We aimed to report a rare collagenous / fibrous type MFB case with emphasis on differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Myofibroblastoma of the Breast

et al. 2015

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This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblastoma (MFB). MFB is one of the rare, benign, spindle-like stromal tumors arising from the connective tissue of the breast. MFBs are often confused with fibroadenomas and hamartomas because of their benign characteristic appearance on breast imaging and are diagnosed after excisional biopsies. Their differential diagnosis with malignant neoplasia of the breast is important because of their wide morphological spectrum. Our case also demonstrated a breast mass with benign imaging characteristics and a needle core biopsy revealing a benign, spindle-like stromal tumor. The pathological examination performed after the excision of the lump demonstrated a collagenous-/ fibrous-type MFB. This case report emphasizes the rare but important place of MFB variants of the breast in the differential diagnosis of breast mass.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myofibroblastoma of the Breast

et al. 2015

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“…Myofibroblasts, fibroblasts, adipocytes, smooth muscle cells, chondrocytes, and osteoblasts can all be encountered in MFBs, expressing their common origin from a precursor stromal cell. Essential elements for diagnosis are the presence of thick hyalinized collagen bundles and low mitotic activity in addition to the lack of myoepithelial component and necrosis [8].…”

Section: Discussionmentioning

confidence: 99%

Myofibroblastoma of the Breast: Diagnostic Challenges of a Rare Benign Tumor

et al. 2013

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Breast myofibroblastomas (MFBs) are rare benign tumors that have recently been recognized as a distinct entity. They are more common in men and often coexist with gynecomastia. Fine needle aspiration cytology or core biopsy should always be performed for triple assessment; however, due to the multiple variants of the tumor, final diagnosis can be safely accomplished only postoperatively with the aid of immunohistochemistry. The main histological characteristic that differentiates MFBs from the majority of malignant mesenchymal breast lesions is the presence of spindle cells in a collagenous background. Low mitotic activity and vimentin and CD34 positivity have been reported as well. Surgical excision retains a pivotal diagnostic and curative role. Local resection is sufficient, but mastectomy can also be advocated either in cases of male patients with coexisting gynecomastia or in females with large tumors. Into this retrospective survey, three cases of breast MFB were consecutively enrolled. Two patients were postmenopausal females and one was male. Relevant literature is briefly reviewed. Clinical features, histogenesis, morphological, and immunochemical findings are discussed, while the role of the current diagnostic and therapeutic management of this uncommon neoplasm is emphasized.

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“…It is usually seen in menopausal women and elderly men. Physical examination reveals a solid and mobile mass on palpation (2,3). Ultrasonography, mammography, and magnetic resonance (MR) imaging can be used for the diagnosis.…”

Section: Introductionmentioning

confidence: 99%